Linked Life Data

10968613

Source:http://linkedlifedata.com/resource/pubmed/id/10968613

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-12-6
pubmed:abstractText
The achievements in the structural characterization in solution, through NMR spectroscopy, of proteins containing metal ions are reviewed and discussed. We call this branch "inorganic structural biology". The results of this approach are presented here for cytochrome b5, used in this paper as a case system. These results are discussed particularly in the light of their relevance for understanding the biological function of the proteins. Furthermore, the extension of the characterization to the internal motions and to the folding/unfolding processes, as well as the development of tools for structure prediction, are critically presented. The message is that the complete characterization of a biological molecule cannot be limited to a static description of the structure but it should go beyond, analyzing the internal motions occurring at various time scales as well as the behavior in different conditions, such as in the presence of denaturing agents.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0949-8257
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
422-31
pubmed:dateRevised
2005-11-16
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Perspectives in inorganic structural biology: solution structures of metalloproteins.
pubmed:affiliation
CERM and Department of Chemistry, University of Florence, Sesto Fiorentino, Italy. banci@cerm.unifi.it
pubmed:publicationType
Journal Article, Review