Linked Life Data

10963955

Source:http://linkedlifedata.com/resource/pubmed/id/10963955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2000-10-5
pubmed:abstractText
It has been proposed that considerable DNA damage may be caused by endogenous metabolites produced during the body's normal metabolic processes. We have previously shown that L-DOPA, in the presence of Cu(II), leads to oxidative DNA breakage in vitro. Bilirubin is a degradation product of heme and is considered to possess antioxidant properties. In this paper we report that bilirubin inhibits L-DOPA-Cu(II)-mediated DNA cleavage to an appreciable extent of 50% at a concentration of 50 microM. Bilirubin was also shown to directly quench the generation of hydroxyl radicals by L-DOPA-Cu(II) to an extent of 30% at a concentration of 20 microM. The results support the putative antioxidant role of bilirubin in higher primates.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0887-2333
pubmed:author
pubmed:issnType
Print
pubmed:volume
14
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
401-4
pubmed:dateRevised
2009-4-10
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Inhibition of L-DOPA-Cu(II)-mediated DNA cleavage by bilirubin.
pubmed:affiliation
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligath (U. P.) 202 002, India.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't