| pubmed-article:10960769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C0086661 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C0162508 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C0023903 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C0033713 | lld:lifeskim |
| pubmed-article:10960769 | lifeskim:mentions | umls-concept:C1152266 | lld:lifeskim |
| pubmed-article:10960769 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:10960769 | pubmed:dateCreated | 2000-10-20 | lld:pubmed |
| pubmed-article:10960769 | pubmed:abstractText | Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens. Methylation of the c-jun and c-myc genes, expression of both genes and DNA methyltransferase (DNA MTase) activity were determined in liver tumors initiated by N-methyl-N-nitrosourea and promoted by DCA and TCA in female B6C3F1 mice. Hypomethylated and over-expression of c-jun and c-myc genes were found in DCA- and TCA-promoted liver tumors. DNA MTase activity was increased in tumors while decreased in non-involved liver. Thus, DCA- and TCA-promoted carcinogenesis appears to include decreased methylation and increased expression of c-jun and c-myc genes in the presence of increased DNA MTase activity. | lld:pubmed |
| pubmed-article:10960769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10960769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10960769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10960769 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:10960769 | pubmed:issn | 0304-3835 | lld:pubmed |
| pubmed-article:10960769 | pubmed:author | pubmed-author:TaoLL | lld:pubmed |
| pubmed-article:10960769 | pubmed:author | pubmed-author:YangSS | lld:pubmed |
| pubmed-article:10960769 | pubmed:author | pubmed-author:PereiraM AMA | lld:pubmed |
| pubmed-article:10960769 | pubmed:author | pubmed-author:XinDD | lld:pubmed |
| pubmed-article:10960769 | pubmed:author | pubmed-author:KramerP MPM | lld:pubmed |
| pubmed-article:10960769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10960769 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10960769 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:10960769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10960769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10960769 | pubmed:pagination | 185-93 | lld:pubmed |
| pubmed-article:10960769 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:10960769 | pubmed:meshHeading | pubmed-meshheading:10960769... | lld:pubmed |
| pubmed-article:10960769 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10960769 | pubmed:articleTitle | Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors. | lld:pubmed |
| pubmed-article:10960769 | pubmed:affiliation | Department of Pathology, Medical College of Ohio, Health Education Building, 3055 Arlington Ave., Toledo, OH 43614-5806, USA. ltao@mco.edu | lld:pubmed |
| pubmed-article:10960769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10960769 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| entrez-gene:16476 | entrezgene:pubmed | pubmed-article:10960769 | lld:entrezgene |
| entrez-gene:17869 | entrezgene:pubmed | pubmed-article:10960769 | lld:entrezgene |
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