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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-10-20
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pubmed:abstractText |
Dichloroacetic acid (DCA) and trichloroacetic acid (TCA) are mouse liver carcinogens. Methylation of the c-jun and c-myc genes, expression of both genes and DNA methyltransferase (DNA MTase) activity were determined in liver tumors initiated by N-methyl-N-nitrosourea and promoted by DCA and TCA in female B6C3F1 mice. Hypomethylated and over-expression of c-jun and c-myc genes were found in DCA- and TCA-promoted liver tumors. DNA MTase activity was increased in tumors while decreased in non-involved liver. Thus, DCA- and TCA-promoted carcinogenesis appears to include decreased methylation and increased expression of c-jun and c-myc genes in the presence of increased DNA MTase activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alkylating Agents,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Dichloroacetate,
http://linkedlifedata.com/resource/pubmed/chemical/Methylnitrosourea,
http://linkedlifedata.com/resource/pubmed/chemical/Methyltransferases,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-jun,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-myc,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trichloroacetic Acid
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0304-3835
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
158
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
185-93
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10960769-Alkylating Agents,
pubmed-meshheading:10960769-Animals,
pubmed-meshheading:10960769-Blotting, Northern,
pubmed-meshheading:10960769-Blotting, Southern,
pubmed-meshheading:10960769-Blotting, Western,
pubmed-meshheading:10960769-DNA, Neoplasm,
pubmed-meshheading:10960769-DNA Methylation,
pubmed-meshheading:10960769-Dichloroacetate,
pubmed-meshheading:10960769-Female,
pubmed-meshheading:10960769-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10960769-Liver Neoplasms, Experimental,
pubmed-meshheading:10960769-Methylnitrosourea,
pubmed-meshheading:10960769-Methyltransferases,
pubmed-meshheading:10960769-Mice,
pubmed-meshheading:10960769-Promoter Regions, Genetic,
pubmed-meshheading:10960769-Proto-Oncogene Proteins c-jun,
pubmed-meshheading:10960769-Proto-Oncogene Proteins c-myc,
pubmed-meshheading:10960769-RNA, Messenger,
pubmed-meshheading:10960769-Trichloroacetic Acid
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pubmed:year |
2000
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pubmed:articleTitle |
Hypomethylation and overexpression of c-jun and c-myc protooncogenes and increased DNA methyltransferase activity in dichloroacetic and trichloroacetic acid-promoted mouse liver tumors.
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pubmed:affiliation |
Department of Pathology, Medical College of Ohio, Health Education Building, 3055 Arlington Ave., Toledo, OH 43614-5806, USA. ltao@mco.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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