Linked Life Data

10953201

Source:http://linkedlifedata.com/resource/pubmed/id/10953201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2000-8-31
pubmed:abstractText
The addition of valproic acid (VPA) to a lamotrigine monotherapy regimen (LTG) results in a decrement of LTG clearance. Whether this effect is related to the dose or concentration at steady state (Css) of VPA is yet to be established. This study was conducted to determine whether the dose or Css of VPA were inversely related to LTG clearance in 28 patients with intractable epilepsy who were treated with a combination of LTG and VPA. Correlations between LTG clearance and the dose and Css of VPA and comparisons of LTG clearance during low and high doses of VPA demonstrated that the degree of inhibition of LTG clearance is independent of the dose and Css of VPA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0028-3878
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
55
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
588-91
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Adding valproate to lamotrigine: a study of their pharmacokinetic interaction.
pubmed:affiliation
Section of Epilepsy and Clinical Neurophysiology, Department of Neurological Sciences, Rush Medical College, and Rush Epilepsy Center, Rush-Presbyterian Saint Luke's Medical Center, Chicago, IL 60612, USA. akanner@neuro.rpstlmc.edu
pubmed:publicationType
Journal Article, Clinical Trial