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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2000-9-6
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pubmed:abstractText |
Considerable evidence suggests that hyperhomocysteinemia is an independent vascular risk factor that promotes atherosclerosis by inducing endothelial dysfunction. Although folic acid reduces hyperhomocysteinemia, the effect on adverse vascular events is unknown. We hypothesized that in patients with chronic renal failure, a condition associated with both hyperhomocysteinemia and atherosclerosis, treatment with folic acid would improve endothelial function.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
102
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
871-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10952955-Aged,
pubmed-meshheading:10952955-Brachial Artery,
pubmed-meshheading:10952955-Double-Blind Method,
pubmed-meshheading:10952955-Endothelium, Vascular,
pubmed-meshheading:10952955-Erythrocytes,
pubmed-meshheading:10952955-Female,
pubmed-meshheading:10952955-Folic Acid,
pubmed-meshheading:10952955-Hematinics,
pubmed-meshheading:10952955-Homocysteine,
pubmed-meshheading:10952955-Humans,
pubmed-meshheading:10952955-Kidney Failure, Chronic,
pubmed-meshheading:10952955-Male,
pubmed-meshheading:10952955-Middle Aged,
pubmed-meshheading:10952955-Nitrates,
pubmed-meshheading:10952955-Nitrites,
pubmed-meshheading:10952955-Placebos,
pubmed-meshheading:10952955-Prospective Studies,
pubmed-meshheading:10952955-Renal Dialysis,
pubmed-meshheading:10952955-Vasodilation,
pubmed-meshheading:10952955-von Willebrand Factor
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pubmed:year |
2000
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pubmed:articleTitle |
Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure?
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pubmed:affiliation |
Division of Medical Sciences (Cardiology), University of Birmingham Birmingham, UK. J.Thambyrajah@bham.ac.uk
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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