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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1979-8-29
|
| pubmed:abstractText |
A monoclonal IgG4 (lambda) with inhibitory activity to human coagulation factor V was isolated from the serum of a patient with a fatal hemorrhagic diathesis by using a combination of DE-52 ion exchange chromatography and isoelectric focusing techniques. Using the criteria for defining a monoclonal immunoglobulin of restricted mobility on protein electrophoresis, immunoelectrophoresis, and isoelectric focusing, as well as neutralization with class, subclass, and light chain type antisera, we are the first to demonstrate a factor V inhibitor as a monoclonal IgG4 (lambda) detectable in serum or plasma.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0022-1767
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
122
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2119-21
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:109525-Chromatography, Ion Exchange,
pubmed-meshheading:109525-Clone Cells,
pubmed-meshheading:109525-Factor V,
pubmed-meshheading:109525-Humans,
pubmed-meshheading:109525-Immune Sera,
pubmed-meshheading:109525-Immunoglobulin G,
pubmed-meshheading:109525-Immunoglobulin lambda-Chains,
pubmed-meshheading:109525-Isoelectric Focusing,
pubmed-meshheading:109525-Neutralization Tests
|
| pubmed:year |
1979
|
| pubmed:articleTitle |
A monoclonal IgG4 (lambda) with factor V inhibitory activity.
|
| pubmed:publicationType |
Journal Article
|