Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
2000-9-25
pubmed:abstractText
Different ofloxacin-loaded unilamellar vesicles were prepared by the extrusion technique, and their antimicrobial activities were determined in comparison to those of the free drug by means of MIC determinations with both American Type Culture Collection standards and wild-type bacterial strains (six strains of Enterococcus faecalis, seven strains of Escherichia coli, six strains of Staphylococcus aureus, and six strains of Pseudomonas aeruginosa). The accumulation of ofloxacin and liposome-ofloxacin was measured by determining the amount of the drug inside the bacteria as a function of time. Encapsulated fluoroquinolone yielded MICs which were at least twofold lower than those obtained with the free drug. In particular, liposomes made up of dimyristoylphosphatidylcholine-cholesterol-dipalmitoylphosphatidylser ine and dimyristoylphosphatidylcholine-cholesterol-dihexadecylphosphate (4:3:4 molar ratio) provided the best improvement in antimicrobial activity against the various bacterial strains investigated. The liposome formulation produced higher intracellular fluoroquinolone concentrations than those achieved simultaneously with the free drug in both E. coli and P. aeruginosa.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-10224339, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-10381102, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-10553699, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-10590306, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-10600113, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-10726888, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-1275238, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-1423280, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-1454532, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-1489194, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-1663928, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-1864283, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-1938683, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-2502066, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-2514623, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-2580220, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-2692513, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-2831810, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-2837141, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-3015873, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-3111356, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-3132091, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-4005257, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-6168679, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-629935, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-6450335, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-6527250, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-6662833, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-7470445, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-7492103, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-7562444, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-7574534, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-8069561, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-8360125, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-8592684, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-8611968, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-8865150, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9124856, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9449262, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9551236, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9551238, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9578167, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9829160, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9871938, http://linkedlifedata.com/resource/pubmed/commentcorrection/10952595-9875416
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0066-4804
pubmed:author
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2458-64
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Ofloxacin-loaded liposomes: in vitro activity and drug accumulation in bacteria.
pubmed:affiliation
Department of Microbiological Sciences, University of Catania, Italy. furneri@mbox.unict.it
pubmed:publicationType
Journal Article, Comparative Study