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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2000-8-31
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pubmed:databankReference |
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pubmed:abstractText |
A screen for synthetic enhancers of sli-1 identified ark-1 (forAck-related tyrosine kinase), a novel inhibitor of let-23 EGFR signaling in C. elegans. An ark-1 mutation synergizes with mutations in other negative regulators of let-23, resulting in increased RAS signaling. Genetic analysis suggests that ARK-1 acts upstream of RAS and is dependent upon SEM-5. ARK-1 inhibits LET-23-mediated ovulation, a RAS-independent function. ARK-1 physically interacts with SEM-5 in the yeast two-hybrid assay. We find that sem-5 also has a negative function in let-23-mediated ovulation and suggest that this negative function is mediated by the recruitment of inhibitors such as ARK-1.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1097-2765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
65-75
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10949028-Amino Acid Sequence,
pubmed-meshheading:10949028-Animals,
pubmed-meshheading:10949028-Caenorhabditis elegans,
pubmed-meshheading:10949028-Caenorhabditis elegans Proteins,
pubmed-meshheading:10949028-Cloning, Molecular,
pubmed-meshheading:10949028-Female,
pubmed-meshheading:10949028-Fertility,
pubmed-meshheading:10949028-Genes, Helminth,
pubmed-meshheading:10949028-Genes, Lethal,
pubmed-meshheading:10949028-Genes, ras,
pubmed-meshheading:10949028-Helminth Proteins,
pubmed-meshheading:10949028-Models, Biological,
pubmed-meshheading:10949028-Molecular Sequence Data,
pubmed-meshheading:10949028-Mutation,
pubmed-meshheading:10949028-Ovulation,
pubmed-meshheading:10949028-Protein-Tyrosine Kinases,
pubmed-meshheading:10949028-Receptor, Epidermal Growth Factor,
pubmed-meshheading:10949028-Sequence Homology, Amino Acid,
pubmed-meshheading:10949028-Signal Transduction,
pubmed-meshheading:10949028-Two-Hybrid System Techniques,
pubmed-meshheading:10949028-Vulva
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pubmed:year |
2000
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pubmed:articleTitle |
ARK-1 inhibits EGFR signaling in C. elegans.
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pubmed:affiliation |
MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. nah@mrc-lmb.cam.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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