Source:http://linkedlifedata.com/resource/pubmed/id/10946297
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
2000-9-19
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| pubmed:abstractText |
c-Jun N-terminal kinase (JNK) is a mitogen-activated protein kinase that plays important regulatory roles in helper T cell differentiation. In the current study, we used Jnk1-deficient mice to examine the function of JNK during an in vivo pathogenic infection, leishmaniasis, which is strongly influenced by Th1/Th2 effector mechanisms. The data show that Jnk1-deficient mice, despite their usually genetically resistant background, were unable to resolve Leishmania infections. Jnk1-/- mice displayed reduced delayed-type hypersensitivity in response to the pathogen, which was associated with a T cell defect. We found that, although these mice can direct an apparent Th1-response, there is also simultaneous generation of Leishmania-specific Th2 responses, which possibly down-modulate protective Th1-mediated immune function. These findings demonstrate that the negative regulation of Th2 cytokine production by the JNK1 signaling pathway is essential for generating Th1-polarized immunity against intracellular pathogens, such as Leishmania major.
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| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
0022-1767
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
165
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
2671-6
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:10946297-Animals,
pubmed-meshheading:10946297-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10946297-Cell Differentiation,
pubmed-meshheading:10946297-Cytokines,
pubmed-meshheading:10946297-Hypersensitivity, Delayed,
pubmed-meshheading:10946297-Immunity, Cellular,
pubmed-meshheading:10946297-Leishmania major,
pubmed-meshheading:10946297-Leishmaniasis, Cutaneous,
pubmed-meshheading:10946297-Lymphocyte Activation,
pubmed-meshheading:10946297-Mice,
pubmed-meshheading:10946297-Mice, Inbred BALB C,
pubmed-meshheading:10946297-Mice, Inbred C57BL,
pubmed-meshheading:10946297-Mice, Knockout,
pubmed-meshheading:10946297-Mitogen-Activated Protein Kinase 8,
pubmed-meshheading:10946297-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10946297-T-Lymphocyte Subsets,
pubmed-meshheading:10946297-Th1 Cells,
pubmed-meshheading:10946297-Th2 Cells
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
JNK1 is required for T cell-mediated immunity against Leishmania major infection.
|
| pubmed:affiliation |
Section of Immunobiology, Yale University School of Medicine, and Howard Hughes Medical Institute New Haven, CT 06520, USA.
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| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|