Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2000-9-13
pubmed:abstractText
The role of TGF-beta1 in the regulation of T cell responses has been perplexing, possibly because it is dependent on the type of T cell being regulated and its cytokine microenvironment. In the present study, we demonstrate that TGF-beta1 has a profound inhibitory effect on naive CD4+ T cell undergoing differentiation under defined neutral, Th1 and Th2 priming conditions. In addition, we show that if CD4+ T cells are primed in the presence of TGF-beta1, they exhibit reduced secondary anti-CD3/anti-CD28-induced and antigen-specific immune responses (even when TGF-beta is absent during the secondary response), which is not due to reduced expression of co-stimulatory molecules or to inadequate IL-2 production. Finally, with respect to the effect of TGF-beta on fully differentiated antigen-specific memory CD4+ T cells, we demonstrate that while antigen-specific activation and cytokine secretion by memory Th1 T cells is inhibited by TGF-beta1, such inhibition is associated with partial down-regulation of IL-12 receptor beta2 chain expression. In contrast, memory Th2 T cells are not subject to TGF-beta1 -mediated suppression. In summary, these studies reveal that TGF-beta1 is a powerful negative regulator of the primary immune response of CD4+ T cells, but only Th1 T cells are subject to such regulation after the memory stage of T cell differentiation has been reached. Thus, these studies define the potential regulatory role of TGF-beta1 in Th1 and Th2 T cell-mediated autoimmunity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Il12rb1 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Il12rb2 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2, http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4, http://linkedlifedata.com/resource/pubmed/chemical/OVA 323-339, http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin, http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-12, http://linkedlifedata.com/resource/pubmed/chemical/STAT4 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/STAT6 Transcription Factor, http://linkedlifedata.com/resource/pubmed/chemical/Stat4 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Stat6 protein, mouse, http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators, http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2101-11
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10940900-Animals, pubmed-meshheading:10940900-Apoptosis, pubmed-meshheading:10940900-Cell Differentiation, pubmed-meshheading:10940900-Cells, Cultured, pubmed-meshheading:10940900-DNA-Binding Proteins, pubmed-meshheading:10940900-Immunologic Memory, pubmed-meshheading:10940900-Interferon-gamma, pubmed-meshheading:10940900-Interleukin-2, pubmed-meshheading:10940900-Interleukin-4, pubmed-meshheading:10940900-Mice, pubmed-meshheading:10940900-Mice, Inbred BALB C, pubmed-meshheading:10940900-Ovalbumin, pubmed-meshheading:10940900-Peptide Fragments, pubmed-meshheading:10940900-Phosphorylation, pubmed-meshheading:10940900-Receptors, Interleukin, pubmed-meshheading:10940900-Receptors, Interleukin-12, pubmed-meshheading:10940900-STAT4 Transcription Factor, pubmed-meshheading:10940900-STAT6 Transcription Factor, pubmed-meshheading:10940900-Th1 Cells, pubmed-meshheading:10940900-Th2 Cells, pubmed-meshheading:10940900-Trans-Activators, pubmed-meshheading:10940900-Transforming Growth Factor beta
pubmed:year
2000
pubmed:articleTitle
The effect of TGF-beta1 on immune responses of naïve versus memory CD4+ Th1/Th2 T cells.
pubmed:affiliation
Mucosal Immunity Section, LCI, NIAID, NIH, Bethesda 20892-1890, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't