Linked Life Data

10940648

Source:http://linkedlifedata.com/resource/pubmed/id/10940648

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2000-10-10
pubmed:abstractText
The Fischer 344 rat was found to be extremely sensitive to the diabetogenic effects of neonatally injected streptozotocin (STZ): injection of 40-100 mg/kg STZ at 1.5 days postnatal produced in the adult graded levels of hyperglycemia in males but not the females. The optimal dose in the 1.5 day old male was 80 mg/kg: it produced hyperglycemia without affecting growth or thyroid status in the adult. The neonatally STZ-injected adult rat displayed characteristics consistent with type II diabetes: mild hyperglycemia accentuated by fasting or consumption of a high fat diet; little change in insulin levels; slight elevation in glucagon levels; no alterations in ketones. Using radioligand binding techniques to isolated rat liver plasma membranes, compared to the control state, the type II diabetic state was found to have: no effect on either alpha(2)- or beta-adrenergic receptor binding; a decrease in the major dominant alpha(1)-adrenergic receptor, reflecting a decrease in receptor numbers but not their affinity; an increase in the plasma membrane calcium transport system, potentially depleting intracellular calcium stores essential for producing an alpha(1)-adrenergic receptor response. Since the alpha(1)-adrenergic receptor-calcium effector system is critical for the actions of catecholamines in the rat, these results suggest that the liver in the type II diabetic state may be refractory to the actions of catecholamines. We propose that the diabetes-evoked decrease in the dominant adrenergic receptor-effector system through which catecholamines act may be the cellular expression of defective glucocounterregulation in the diabetic state.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1357-2725
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
905-19
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:10940648-Adrenergic alpha-Antagonists, pubmed-meshheading:10940648-Animals, pubmed-meshheading:10940648-Animals, Newborn, pubmed-meshheading:10940648-Blood Glucose, pubmed-meshheading:10940648-Body Weight, pubmed-meshheading:10940648-Calcium, pubmed-meshheading:10940648-Cell Membrane, pubmed-meshheading:10940648-Diabetes Mellitus, Experimental, pubmed-meshheading:10940648-Diabetes Mellitus, Type 2, pubmed-meshheading:10940648-Dietary Fats, pubmed-meshheading:10940648-Disease Models, Animal, pubmed-meshheading:10940648-Dose-Response Relationship, Drug, pubmed-meshheading:10940648-Female, pubmed-meshheading:10940648-Hormones, pubmed-meshheading:10940648-Insulin, pubmed-meshheading:10940648-Liver, pubmed-meshheading:10940648-Male, pubmed-meshheading:10940648-Rats, pubmed-meshheading:10940648-Rats, Inbred F344, pubmed-meshheading:10940648-Receptors, Adrenergic, pubmed-meshheading:10940648-Sex Characteristics, pubmed-meshheading:10940648-Streptozocin, pubmed-meshheading:10940648-Time Factors, pubmed-meshheading:10940648-gamma-Glutamyltransferase
pubmed:year
2000
pubmed:articleTitle
Neonatal STZ model of type II diabetes mellitus in the Fischer 344 rat: characteristics and assessment of the status of the hepatic adrenergic receptors.
pubmed:affiliation
Department of Physiology, College of Medicine, University of Saskatchewan, 107 Wiggins Road, Saskatoon, Saskatchewan, S7N 5E5, Canada. hemmings@sask.usask.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't