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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
17
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pubmed:dateCreated |
2000-9-21
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pubmed:abstractText |
Overexpression of the MutS repair protein significantly decreased the rate of lacZ GC --> TA transversion mutation in stationary-phase and exponentially growing bacteria and in mutY and mutM mutants, which accumulate mismatches between 8-oxoguanine (8-oxoG) and adenine residues in DNA. Conversely, GC --> TA transversion increased in mutL or mutS mutants in stationary phase. In contrast, overexpression of MutS did not appreciably reduce lacZ AT --> CG transversion mutation in a mutT mutant. These results suggest that MutS-dependent repair can correct 8-oxoG:A mismatches in Escherichia coli cells but may not be able to compete with mutation fixation by MutY in mutT mutants.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-10026220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-10199405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-10438551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-10455196,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-10518225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-10690404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-10734142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-1328155,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-1445834,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-1495996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-1542666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-1601880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-1756965,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-2199309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-2536011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-2834393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-3057502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-3128795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-7984093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8242489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8320213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8510665,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8636043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8676878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8736526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8811176,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-8824540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-9308969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-9393714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-9482750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-9535910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-9801308,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10940054-9880500
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cystine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Guanine,
http://linkedlifedata.com/resource/pubmed/chemical/MutS DNA Mismatch-Binding Protein,
http://linkedlifedata.com/resource/pubmed/chemical/MutS protein, E coli,
http://linkedlifedata.com/resource/pubmed/chemical/Thymine
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0021-9193
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
182
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5025-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:10940054-Adenine,
pubmed-meshheading:10940054-Adenosine Triphosphatases,
pubmed-meshheading:10940054-Bacterial Proteins,
pubmed-meshheading:10940054-Base Pair Mismatch,
pubmed-meshheading:10940054-Cystine,
pubmed-meshheading:10940054-DNA Repair,
pubmed-meshheading:10940054-DNA-Binding Proteins,
pubmed-meshheading:10940054-Escherichia coli,
pubmed-meshheading:10940054-Escherichia coli Proteins,
pubmed-meshheading:10940054-Gene Expression,
pubmed-meshheading:10940054-Genes, Bacterial,
pubmed-meshheading:10940054-Guanine,
pubmed-meshheading:10940054-MutS DNA Mismatch-Binding Protein,
pubmed-meshheading:10940054-Mutation,
pubmed-meshheading:10940054-Thymine
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pubmed:year |
2000
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pubmed:articleTitle |
Reduction of GC --> TA transversion mutation by overexpression of MutS in Escherichia coli K-12.
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pubmed:affiliation |
Department of Microbiology and Molecular Genetics, University of Texas Houston Medical School, Houston, Texas 77030, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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