Linked Life Data

10936061

Source:http://linkedlifedata.com/resource/pubmed/id/10936061

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-11-2
pubmed:abstractText
The interferons (IFNs) play an integral role in cellular host defense against virus infection and conceivably tumorigenesis. Despite over 50 years of research, however, the molecular mechanisms underlining IFN action remain to be fully elucidated, in part because of the large number of genes, with an uncharacterized function that appears to be induced by these cytokines. Although the majority of in vitro studies indicate that IFNs antiviral properties involve inhibiting viral replication while maintaining the integrity of the cell, numerous reports have now implicated that a number of IFN-induced genes, IFN transcriptional regulatory factors and IFN signaling molecules can also mediate apoptosis. Here, we review some of what is known about IFN's ability to invoke programmed cell death as part of an intricate arsenal intended to prevent viral infection and malignant disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1044-579X
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
103-11
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
The interferons and cell death: guardians of the cell or accomplices of apoptosis?
pubmed:affiliation
Department of Microbiology and Immunology and the Sylvester Comprehensive Cancer Center, The University of Miami School of Medicine, FL 33136, USA. gbarber@med.miami.edu
pubmed:publicationType
Journal Article, Review