rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
7
|
pubmed:dateCreated |
2000-11-8
|
pubmed:abstractText |
A functional single-nucleotide variant of the gene encoding the beta3 subunit of heterotrimeric G proteins (Gbeta3 C825T), associated with enhanced G-protein activation and increased activity of the sodium-proton exchanger (NHE1), has been implicated in the development of hypertension. Given the possible involvement of NHE1 in sodium homeostasis, we tested the hypothesis that the Gbeta3 825T allele determines the response of the renin-angiotensin system and blood pressure to dietary salt restriction.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
|
pubmed:status |
MEDLINE
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pubmed:month |
Jul
|
pubmed:issn |
0263-6352
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
18
|
pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
pubmed:pagination |
855-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10930182-Adult,
pubmed-meshheading:10930182-Alleles,
pubmed-meshheading:10930182-Blood Pressure,
pubmed-meshheading:10930182-DNA,
pubmed-meshheading:10930182-Diet, Sodium-Restricted,
pubmed-meshheading:10930182-Genetic Markers,
pubmed-meshheading:10930182-Genotype,
pubmed-meshheading:10930182-Heterotrimeric GTP-Binding Proteins,
pubmed-meshheading:10930182-Humans,
pubmed-meshheading:10930182-Hypertension,
pubmed-meshheading:10930182-Male,
pubmed-meshheading:10930182-Polymerase Chain Reaction,
pubmed-meshheading:10930182-Polymorphism, Genetic,
pubmed-meshheading:10930182-Renin-Angiotensin System,
pubmed-meshheading:10930182-Sodium,
pubmed-meshheading:10930182-Sodium, Dietary,
pubmed-meshheading:10930182-Sodium-Hydrogen Antiporter
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pubmed:year |
2000
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pubmed:articleTitle |
G-protein beta3 subunit 825T allele and response to dietary salt in normotensive men.
|
pubmed:affiliation |
Department of Internal Medicine, Universitätsklinikum Benjamin Franklin, Free University of Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Research Support, Non-U.S. Gov't
|