Source:http://linkedlifedata.com/resource/pubmed/id/10927637
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-1-26
|
| pubmed:abstractText |
Micromolar concentrations of the biologically active oestrogen 17beta-oestradiol reduce agonist-induced force in vascular preparations through an unidentified mechanism. The aim of the present study was to investigate the importance of oestrogen receptor beta (ERbeta) for oestrogen-induced vascular relaxation. 17beta-oestradiol was added to aortic rings from ERbeta knock-out (-/-) and wild-type (+/+) mice precontracted with noradrenaline. 17beta-oestradiol caused a concentration-dependent (1-100 microM) relaxation of aortic rings from both -/- and +/+ animals of both sexes. Rings from male and female -/- mice were more sensitive to 17beta-oestradiol than those from +/+ mice. Medial thickness, determined by computerized image analysis, was similar in rings from -/- and +/+ animals. Endothelium, as determined by immuno-cytochemistry, was present in -/- and +/+ aorta. Maximal noradrenaline evoked force and sensitivity to noradrenaline were similar in both groups. In summary ERbeta modulates vascular relaxation to microM concentrations of oestrogen; lack of ERbeta renders the vascular wall supersensitive to 17beta-oestradiol. Lack of ERbeta caused no change in vascular wall morphology suggesting that this ER subtype is not involved in vascular structure development.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-0795
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
166
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
R5-9
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:10927637-Animals,
pubmed-meshheading:10927637-Aorta,
pubmed-meshheading:10927637-Body Weight,
pubmed-meshheading:10927637-Dose-Response Relationship, Drug,
pubmed-meshheading:10927637-Endothelium, Vascular,
pubmed-meshheading:10927637-Estradiol,
pubmed-meshheading:10927637-Estrogen Receptor beta,
pubmed-meshheading:10927637-Female,
pubmed-meshheading:10927637-Image Processing, Computer-Assisted,
pubmed-meshheading:10927637-Immunohistochemistry,
pubmed-meshheading:10927637-Male,
pubmed-meshheading:10927637-Mice,
pubmed-meshheading:10927637-Mice, Knockout,
pubmed-meshheading:10927637-Microscopy, Fluorescence,
pubmed-meshheading:10927637-Muscle, Smooth, Vascular,
pubmed-meshheading:10927637-Norepinephrine,
pubmed-meshheading:10927637-Receptors, Estrogen,
pubmed-meshheading:10927637-Vasoconstriction
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Increased magnitude of relaxation to oestrogen in aorta from oestrogen receptor beta knock-out mice.
|
| pubmed:affiliation |
Department of Physiological Sciences, Lund University, Sölvegatan 19, S-223 62 Lund, Sweden.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
|