Source:http://linkedlifedata.com/resource/pubmed/id/10924905
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2000-9-29
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pubmed:abstractText |
Cytochrome-c oxidase aa3 (CcO) from Paracoccus denitrificans interacts with tertiary butyl hydroperoxide (t-Bu-O-O-H, TBHP) by forming an adduct as indicated by an absorption shift at 408/432 nm and the induction of photochemical autoreduction. The adduct was stable at room temperature for several days even under aerobic conditions. Upon irradiation (413 nm) of the adduct, a photoproduct, similar to the oxygenated mixed valence species (607 nm form), was formed, as indicated by the 418/442 and 607 nm signals in the absorption-difference spectrum. It is concluded that the adduct formation changes the photochemical properties of heme a3. A molecular model for the binding mechanism of TBHP to CcO and for the photochemistry of heme a3-TBHP adduct is proposed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-3002
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
1459
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-30
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10924905-Electron Transport Complex IV,
pubmed-meshheading:10924905-Models, Molecular,
pubmed-meshheading:10924905-Oxidation-Reduction,
pubmed-meshheading:10924905-Photochemistry,
pubmed-meshheading:10924905-Spectrum Analysis, Raman,
pubmed-meshheading:10924905-tert-Butylhydroperoxide
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pubmed:year |
2000
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pubmed:articleTitle |
Induction of photochemical auto-reduction of cytochrome-c oxidase by an organic peroxide.
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pubmed:affiliation |
Leiden Institute of Chemistry, University of Leiden, The Netherlands. j.matysik@chem.leidenuniv.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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