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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2000-9-7
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pubmed:abstractText |
We previously reported that hypoxia induces the proliferation of cultured mesangial cells mediated by the stimulation of intracellular calcium and the activation of protein kinase C (PKC). In the present study, we examined the roles of mesangial cell specific growth factors (platelet-derived growth factor and endothelin-1) and osteopontin (OPN) in hypoxia-induced proliferation of mesangial cells. In addition, we determined the effect of hypoxia on p38 mitogen-activated protein (MAP) kinase activity and the roles of both PKC and p38 MAP kinase in hypoxia-induced alterations in OPN and mesangial cell growth.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Conditioned,
http://linkedlifedata.com/resource/pubmed/chemical/Culture Media, Serum-Free,
http://linkedlifedata.com/resource/pubmed/chemical/Endothelin-1,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Osteopontin,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet-Derived Growth Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Spp1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/p38 Mitogen-Activated Protein...
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
58
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
691-700
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10916092-Animals,
pubmed-meshheading:10916092-Blood Proteins,
pubmed-meshheading:10916092-Cell Division,
pubmed-meshheading:10916092-Cell Hypoxia,
pubmed-meshheading:10916092-Cells, Cultured,
pubmed-meshheading:10916092-Culture Media, Conditioned,
pubmed-meshheading:10916092-Culture Media, Serum-Free,
pubmed-meshheading:10916092-Endothelin-1,
pubmed-meshheading:10916092-Gene Expression,
pubmed-meshheading:10916092-Glomerular Mesangium,
pubmed-meshheading:10916092-Glomerulosclerosis, Focal Segmental,
pubmed-meshheading:10916092-Ischemia,
pubmed-meshheading:10916092-Male,
pubmed-meshheading:10916092-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10916092-Osteopontin,
pubmed-meshheading:10916092-Oxygen,
pubmed-meshheading:10916092-Platelet-Derived Growth Factor,
pubmed-meshheading:10916092-Protein Kinase C,
pubmed-meshheading:10916092-RNA, Messenger,
pubmed-meshheading:10916092-Rats,
pubmed-meshheading:10916092-Rats, Sprague-Dawley,
pubmed-meshheading:10916092-Sialoglycoproteins,
pubmed-meshheading:10916092-p38 Mitogen-Activated Protein Kinases
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pubmed:year |
2000
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pubmed:articleTitle |
Osteopontin mediates hypoxia-induced proliferation of cultured mesangial cells: role of PKC and p38 MAPK.
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pubmed:affiliation |
Division of Nephrology and Hypertension, Northwestern University Medical School, Chicago, IL 60611, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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