Source:http://linkedlifedata.com/resource/pubmed/id/10915076
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2000-9-26
|
| pubmed:abstractText |
In Kenya, the median incubation time to AIDS in seroconverting sex workers is 4 years; this incubation time is specific to female sex workers. We studied the influence of acute sexually transmitted infections (STIs) on several immunologic parameters in 32 human immunodeficiency virus type 1 (HIV-1)-positive and 10 HIV-1-negative women sex workers who were followed for 1-5 months. Plasma cytokines, soluble cytokine receptors, CD4 and CD8 T cell counts, and HIV-1 plasma viremia were quantitated before, during, and after episodes of STI. Increases in interleukin (IL)-4, IL-6, IL-10, soluble tumor necrosis factor (TNF)-alpha, and viremia and a decline in CD4(+) T cell counts occurred during gonococcal cervicitis and returned to baseline after treatment. Increases in viremia correlated with increased IL-4 and decreased IL-6 concentrations. Similar changes were seen among women with acute pelvic inflammatory disease. Acute bacterial STI resulted in increased HIV-1 viremia. This may be mediated through increased inflammatory cytokines or through modulation of immune responses that control HIV-1 viremia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1899
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
182
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
459-66
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:10915076-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10915076-Acute Disease,
pubmed-meshheading:10915076-Adolescent,
pubmed-meshheading:10915076-Adult,
pubmed-meshheading:10915076-CD4 Lymphocyte Count,
pubmed-meshheading:10915076-CD4-Positive T-Lymphocytes,
pubmed-meshheading:10915076-Cohort Studies,
pubmed-meshheading:10915076-Cytokines,
pubmed-meshheading:10915076-Disease Progression,
pubmed-meshheading:10915076-Female,
pubmed-meshheading:10915076-HIV Infections,
pubmed-meshheading:10915076-HIV-1,
pubmed-meshheading:10915076-Humans,
pubmed-meshheading:10915076-Interleukins,
pubmed-meshheading:10915076-Kenya,
pubmed-meshheading:10915076-Middle Aged,
pubmed-meshheading:10915076-Prostitution,
pubmed-meshheading:10915076-Sexually Transmitted Diseases,
pubmed-meshheading:10915076-Tumor Necrosis Factor-alpha,
pubmed-meshheading:10915076-Viremia
|
| pubmed:year |
2000
|
| pubmed:articleTitle |
Acute sexually transmitted infections increase human immunodeficiency virus type 1 plasma viremia, increase plasma type 2 cytokines, and decrease CD4 cell counts.
|
| pubmed:affiliation |
Department of Medical Microbiology, University of Manitoba, Winnipeg, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|