Linked Life Data

10913470

Source:http://linkedlifedata.com/resource/pubmed/id/10913470

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-8-17
pubmed:abstractText
Electron-beam computed tomography (EBCT) allows for accurate noninvasive detection and quantification of coronary calcium that is representative of underlying atherosclerotic disease. The present study quantitatively analyzes the topography and establishes the natural history of coronary calcium in patients with variable degrees of coronary atherosclerosis. EBCT was performed in 330 consecutive patients aged 56 +/- 12 years (70% men) with recent (<3 months) onset of signs or symptoms of coronary artery disease (CAD) or who were evaluated because of a presumed high risk. Total calcium scores, computed by the Agatston method, were positive in 269 patients (82%) (mean age 58 +/- 11 years, 73% men). These patients were classified into 4 groups, with total calcium scores ranging between 1 and 30, >30 and 100, >100 and 400, and >400, respectively. The presence and amount of calcium was additionally assessed in 10 major segments of the coronary arterial tree, including the major coronary arteries. Of the 72 patients with calcium of only 1 of the major coronary arteries, the left anterior descending coronary artery was involved in 39 patients (54%) and the right coronary artery in 18 patients (25%). Left main stem calcium was observed in only 10 of 139 patients (7%) with 1- or 2-vessel calcium and in 17 of 77 patients (23%) with 3-vessel calcium. Calcium was consistent most frequently in the proximal left anterior descending coronary artery, followed by the proximal left circumflex and right coronary artery segments. A significant decrease of frequency and amount of calcium from the proximal to distal segments was observed in the left coronary system but not in the right coronary artery, where the distribution was more even. With increasing total calcium scores, segmental scores in the more distal segments were enhanced, but the increase was most pronounced in the proximal segments and particularly in the proximal left anterior descending coronary artery. EBCT-derived coronary calcium shows an axial distribution that appears comparable to that of atherosclerotic lesions observed in pathologic and angiographic studies, highlighting the potential role of EBCT for studying the natural history of CAD.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0002-9149
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
86
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
127-32
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Usefulness of topography of coronary calcium by electron-beam computed tomography in predicting the natural history of coronary atherosclerosis.
pubmed:affiliation
Department of Cardiology, University Clinic Essen, Essen, Germany. axel.Schmermund@uni-essen.de
pubmed:publicationType
Journal Article