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rdf:type |
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lifeskim:mentions |
umls-concept:C0003873,
umls-concept:C0016030,
umls-concept:C0017262,
umls-concept:C0030685,
umls-concept:C0033684,
umls-concept:C0035696,
umls-concept:C0069676,
umls-concept:C0185117,
umls-concept:C0225369,
umls-concept:C0391871,
umls-concept:C0521339,
umls-concept:C0680255,
umls-concept:C0962754,
umls-concept:C1280500,
umls-concept:C1283071,
umls-concept:C1550315,
umls-concept:C1963578,
umls-concept:C2911684
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pubmed:issue |
7
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pubmed:dateCreated |
2000-8-8
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|
pubmed:abstractText |
Osteopontin (OPN) is an extracellular matrix protein that has been implicated in the interactions between tumor cells and host matrix, including those involved in invasion and spread of tumor cells. Because joint destruction in rheumatoid arthritis (RA) is mediated by the invasive growth of synovial tissue through its attachment to cartilage, we examined the expression of OPN in the synovia of patients with RA and the effect of OPN on the production of collagenase 1 in rheumatoid synovial fibroblasts and articular chondrocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/CD68 antigen, human,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Osteopontin,
http://linkedlifedata.com/resource/pubmed/chemical/Procollagen-Proline Dioxygenase,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SPP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Spp1 protein, rat
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0004-3591
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pubmed:author |
pubmed-author:ChangP LPL,
pubmed-author:FranzJ KJK,
pubmed-author:GayR ERE,
pubmed-author:GaySS,
pubmed-author:HummelK MKM,
pubmed-author:KleinC LCL,
pubmed-author:KriegsmannJJ,
pubmed-author:Müller-LadnerUU,
pubmed-author:PetrowP KPK,
pubmed-author:PrinceC WCW,
pubmed-author:SchedelJJ
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pubmed:issnType |
Print
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pubmed:volume |
43
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1597-605
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10902765-Aged,
pubmed-meshheading:10902765-Animals,
pubmed-meshheading:10902765-Antigens, CD,
pubmed-meshheading:10902765-Antigens, Differentiation, Myelomonocytic,
pubmed-meshheading:10902765-Arthritis, Rheumatoid,
pubmed-meshheading:10902765-Cells, Cultured,
pubmed-meshheading:10902765-Chondrocytes,
pubmed-meshheading:10902765-Female,
pubmed-meshheading:10902765-Fibroblasts,
pubmed-meshheading:10902765-Humans,
pubmed-meshheading:10902765-Immunohistochemistry,
pubmed-meshheading:10902765-In Situ Hybridization,
pubmed-meshheading:10902765-Male,
pubmed-meshheading:10902765-Matrix Metalloproteinase 1,
pubmed-meshheading:10902765-Middle Aged,
pubmed-meshheading:10902765-Osteopontin,
pubmed-meshheading:10902765-Procollagen-Proline Dioxygenase,
pubmed-meshheading:10902765-RNA, Messenger,
pubmed-meshheading:10902765-Rats,
pubmed-meshheading:10902765-Recombinant Proteins,
pubmed-meshheading:10902765-Sialoglycoproteins,
pubmed-meshheading:10902765-Synovial Membrane
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pubmed:year |
2000
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pubmed:articleTitle |
Expression of osteopontin messenger RNA and protein in rheumatoid arthritis: effects of osteopontin on the release of collagenase 1 from articular chondrocytes and synovial fibroblasts.
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pubmed:affiliation |
University Hospital, Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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