| pubmed-article:10900358 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0002395 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C1308752 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0333735 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0524914 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C1332822 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C1366765 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C1367714 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C1706327 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0023688 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0205250 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:10900358 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:10900358 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:10900358 | pubmed:dateCreated | 2000-8-25 | lld:pubmed |
| pubmed-article:10900358 | pubmed:abstractText | Inflammatory mediators have been implicated in the pathophysiology of neurodegenerative diseases. Here we report the presence of the chemokine receptor CXCR3 and its ligand, IP-10, in normal and Alzheimer's disease (AD) brains. CXCR3 was detected constitutively on neurons and neuronal processes in various cortical and subcortical regions; IP-10 was observed in a subpopulation of astrocytes in normal brain, and was markedly elevated in astrocytes in AD brains. Many IP-10(+) astrocytes were associated with senile plaques and had an apparently coordinated upregulation of MIP-1beta. Moreover, we showed that CXCR3 ligands, IP-10 and Mig, were able to activate ERK1/2 pathway in mouse cortical neurons, suggesting a novel mechanism of neuronal-glial interaction. | lld:pubmed |
| pubmed-article:10900358 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10900358 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10900358 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10900358 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10900358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:10900358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10900358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10900358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10900358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10900358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10900358 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10900358 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:10900358 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:10900358 | pubmed:author | pubmed-author:RaoV GVG | lld:pubmed |
| pubmed-article:10900358 | pubmed:author | pubmed-author:HymanB TBT | lld:pubmed |
| pubmed-article:10900358 | pubmed:author | pubmed-author:PauW SWS | lld:pubmed |
| pubmed-article:10900358 | pubmed:author | pubmed-author:BacskaiB JBJ | lld:pubmed |
| pubmed-article:10900358 | pubmed:author | pubmed-author:KnowlesR BRB | lld:pubmed |
| pubmed-article:10900358 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10900358 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10900358 | pubmed:volume | 108 | lld:pubmed |
| pubmed-article:10900358 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10900358 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10900358 | pubmed:pagination | 227-35 | lld:pubmed |
| pubmed-article:10900358 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:10900358 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10900358 | pubmed:articleTitle | Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease. | lld:pubmed |
| pubmed-article:10900358 | pubmed:affiliation | Alzheimer's Research, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Harvard, MA 02129, USA. | lld:pubmed |
| pubmed-article:10900358 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10900358 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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