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rdf:type |
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lifeskim:mentions |
umls-concept:C0002395,
umls-concept:C0017262,
umls-concept:C0023688,
umls-concept:C0027882,
umls-concept:C0035820,
umls-concept:C0185117,
umls-concept:C0205250,
umls-concept:C0333735,
umls-concept:C0524914,
umls-concept:C1308752,
umls-concept:C1332822,
umls-concept:C1366765,
umls-concept:C1367714,
umls-concept:C1533691,
umls-concept:C1706327,
umls-concept:C1879547,
umls-concept:C2911684
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-8-25
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pubmed:abstractText |
Inflammatory mediators have been implicated in the pathophysiology of neurodegenerative diseases. Here we report the presence of the chemokine receptor CXCR3 and its ligand, IP-10, in normal and Alzheimer's disease (AD) brains. CXCR3 was detected constitutively on neurons and neuronal processes in various cortical and subcortical regions; IP-10 was observed in a subpopulation of astrocytes in normal brain, and was markedly elevated in astrocytes in AD brains. Many IP-10(+) astrocytes were associated with senile plaques and had an apparently coordinated upregulation of MIP-1beta. Moreover, we showed that CXCR3 ligands, IP-10 and Mig, were able to activate ERK1/2 pathway in mouse cortical neurons, suggesting a novel mechanism of neuronal-glial interaction.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CXCL9 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CXCR3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL4,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL10,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CXCL9,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, CXC,
http://linkedlifedata.com/resource/pubmed/chemical/Cxcr3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Glial Fibrillary Acidic Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Ligands,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Inflammatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CXCR3,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
227-35
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:10900358-Aged,
pubmed-meshheading:10900358-Alzheimer Disease,
pubmed-meshheading:10900358-Animals,
pubmed-meshheading:10900358-Astrocytes,
pubmed-meshheading:10900358-Cells, Cultured,
pubmed-meshheading:10900358-Cerebral Cortex,
pubmed-meshheading:10900358-Chemokine CCL4,
pubmed-meshheading:10900358-Chemokine CXCL10,
pubmed-meshheading:10900358-Chemokine CXCL9,
pubmed-meshheading:10900358-Chemokines, CXC,
pubmed-meshheading:10900358-Enzyme Activation,
pubmed-meshheading:10900358-Female,
pubmed-meshheading:10900358-Gene Expression Profiling,
pubmed-meshheading:10900358-Glial Fibrillary Acidic Protein,
pubmed-meshheading:10900358-Humans,
pubmed-meshheading:10900358-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:10900358-Ligands,
pubmed-meshheading:10900358-MAP Kinase Signaling System,
pubmed-meshheading:10900358-Macrophage Inflammatory Proteins,
pubmed-meshheading:10900358-Mice,
pubmed-meshheading:10900358-Mitogen-Activated Protein Kinases,
pubmed-meshheading:10900358-Neurons,
pubmed-meshheading:10900358-Phosphorylation,
pubmed-meshheading:10900358-Plaque, Amyloid,
pubmed-meshheading:10900358-Receptors, CXCR3,
pubmed-meshheading:10900358-Receptors, Chemokine,
pubmed-meshheading:10900358-Up-Regulation
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pubmed:year |
2000
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pubmed:articleTitle |
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer's disease.
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pubmed:affiliation |
Alzheimer's Research, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Harvard, MA 02129, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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