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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2000-8-25
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pubmed:abstractText |
Opioid-containing immunocytes migrate to inflamed sites where they release beta-endorphin which activates peripheral opioid receptors and produces analgesia. The immigration of immunocytes to sites of inflammation is mediated by adhesion molecules. In this study, the expression of L-, P-, E-selectin and platelet-endothelial adhesion molecule-1 (PECAM-1) in relation to beta-endorphin expression was analyzed by immunohistochemistry in inflamed tissues. The proportion of immunocytes expressing L-selectin was increased in inflamed lymph nodes and subcutaneous paw tissue. P-selectin and PECAM-1 were constitutively expressed on endothelia of noninflamed lymph nodes and subcutaneous tissue and were upregulated in inflammation. beta-endorphin positive cells expressed L-selectin in lymph nodes and subcutaneous tissue. Upregulation of P-selectin and PECAM-1 and the co-localization of L-selectin and beta-endorphin in immunocytes suggest an important role of these adhesion molecules for the recruitment of immunocytes containing beta-endorphin to sites of painful inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-5728
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
160-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10900350-Animals,
pubmed-meshheading:10900350-Antigens, CD31,
pubmed-meshheading:10900350-Cell Adhesion Molecules,
pubmed-meshheading:10900350-Chemotaxis, Leukocyte,
pubmed-meshheading:10900350-Disease Models, Animal,
pubmed-meshheading:10900350-E-Selectin,
pubmed-meshheading:10900350-Freund's Adjuvant,
pubmed-meshheading:10900350-Hindlimb,
pubmed-meshheading:10900350-Immunohistochemistry,
pubmed-meshheading:10900350-Inflammation,
pubmed-meshheading:10900350-L-Selectin,
pubmed-meshheading:10900350-Lymph Nodes,
pubmed-meshheading:10900350-Male,
pubmed-meshheading:10900350-P-Selectin,
pubmed-meshheading:10900350-Pain,
pubmed-meshheading:10900350-Rats,
pubmed-meshheading:10900350-Rats, Wistar,
pubmed-meshheading:10900350-Skin,
pubmed-meshheading:10900350-Up-Regulation,
pubmed-meshheading:10900350-beta-Endorphin
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pubmed:year |
2000
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pubmed:articleTitle |
Co-expression of beta-endorphin with adhesion molecules in a model of inflammatory pain.
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pubmed:affiliation |
Klinik für Anaesthesiologie und operative Intensivmedizin, Freie Universität Berlin, Hindenburgdamm 30, D 12200, Berlin, Germany. Shaaban@zop-admin.ukbf.fu-berlin.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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