Linked Life Data

10899914

Source:http://linkedlifedata.com/resource/pubmed/id/10899914

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2000-8-10
pubmed:abstractText
CD1b and CD1c are antigen-presenting molecules that mediate recognition of bacterial lipids by T cells, but it is currently not known whether these two molecules are redundant or are specialized to perform different immunological functions. Here, we show that the distribution of CD1c in human dendritic cells was characterized by a high ratio of cell surface to intracellular molecules, whereas CD1b showed a reciprocal pattern of distribution. In contrast to the accumulation of CD1b in lysosomal major histocompatibility complex class II compartments, intracellular CD1c molecules accumulated in other endocytic compartments, most likely early and late endosomes. Deletion of the cytoplasmic tail of CD1c, containing a tyrosine-based internalization motif, abolished most of its intracellular localization. Functional studies using T cells specific for defined lipid antigens revealed that in contrast to CD1b-mediated antigen presentation, antigen presentation by CD1c was resistant to drugs inhibiting endosomal acidification and was independent of endosomal localization of CD1c. Taken together, these results support the hypothesis that CD1b and CD1c are specialized to survey the lipid content of different intracellular compartments.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-10087269, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-10358761, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-10626896, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-1281285, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-2462006, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-2477705, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-2582041, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-7484459, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-7527500, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-8662520, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-8816382, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-9366387, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-9488653, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-9529151, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-9709504, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-9874576, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-9886408, http://linkedlifedata.com/resource/pubmed/commentcorrection/10899914-9987600
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-1007
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
192
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
281-8
pubmed:dateRevised
2010-9-14
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Human CD1b and CD1c isoforms survey different intracellular compartments for the presentation of microbial lipid antigens.
pubmed:affiliation
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't