Linked Life Data

10884864

Source:http://linkedlifedata.com/resource/pubmed/id/10884864

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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2000-7-31
pubmed:abstractText
One hundred and eight children with acute, symptomatic, uncomplicated, falciparum malaria were randomized to receive chloroquine (for 3 days) plus chlorpheniramine alone (for seven days) (CQ-CP group; N = 55) or, in a sequential treatment, chloroquine plus chlorpheniramine for 3 days followed, on the fourth day, by a single oral dose of sulfadoxine-pyrimethamine (25 mg sulfadoxine/kg) (CQ-CP-SP group; N = 53). The mean (S.D.) parasite-clearance time in the CQ-CP group [2.1 (0.7) days; range = 1-5 days] was similar to that in the CQ-CP-SP [2.1 (0.8) days; range = 1-5 days]. The fever-clearance times were also similar: 1.2 (0.1) days (range = 1-3 days) v. 1.1 (0.4) days (range = 1-3 days). The cure rates on days 14, 21 and 28 were 98.2%, 96.3% and 92.7%, respectively in the CQ-CP group, and 100%, 100% and 96.2%, respectively, in the CQ-CP-SP group. The rates of gametocyte carriage were low and similar (5.4% in the CQ-CP group and 3.8% in the CQ-CP-SP group) throughout the duration of the study. Both treatment regimens were relatively well tolerated, the main adverse reactions being similar: sleepiness (on day 1) and pruritus (on days 1-3). No adverse effect was attributable to SP. The results indicate that sequential treatment, for 3 days with CQ and CP, followed by a single dose of SP, is effective and well tolerated in children with acute, uncomplicated, falciparum malaria and may be an alternative treatment for CQ- and/or SP-resistant falciparum malaria. Treatment with a CQ-CP combination (CQ and CP for 3 days and then CP alone for another 4 days) is also effective but requires continuing administration after the signs and symptoms of acute malaria have disappeared.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0003-4983
pubmed:author
pubmed:issnType
Print
pubmed:volume
94
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-17
pubmed:dateRevised
2009-5-18
pubmed:meshHeading
pubmed-meshheading:10884864-Animals, pubmed-meshheading:10884864-Antimalarials, pubmed-meshheading:10884864-Antipruritics, pubmed-meshheading:10884864-Child, pubmed-meshheading:10884864-Child, Preschool, pubmed-meshheading:10884864-Chloroquine, pubmed-meshheading:10884864-Chlorpheniramine, pubmed-meshheading:10884864-Drug Administration Schedule, pubmed-meshheading:10884864-Drug Therapy, Combination, pubmed-meshheading:10884864-Fever, pubmed-meshheading:10884864-Germ Cells, pubmed-meshheading:10884864-Humans, pubmed-meshheading:10884864-Infant, pubmed-meshheading:10884864-Malaria, Falciparum, pubmed-meshheading:10884864-Parasitemia, pubmed-meshheading:10884864-Plasmodium falciparum, pubmed-meshheading:10884864-Pyrimethamine, pubmed-meshheading:10884864-Sulfadoxine, pubmed-meshheading:10884864-Treatment Outcome
pubmed:year
2000
pubmed:articleTitle
Comparative efficacy of chloroquine plus chlorpheniramine alone and in a sequential combination with sulfadoxine-pyrimethamine, for the treatment of acute, uncomplicated, falciparum malaria in children.
pubmed:affiliation
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria. malaria.iba@alpha.linkserve.com
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't