Source:http://linkedlifedata.com/resource/pubmed/id/10877123
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2000-11-13
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pubmed:abstractText |
Play behaviours are exhibited by many mammalian species. The similarity of such behaviour across children, non-human primates and rats makes it an especially appropriate target for the investigation of drug- or toxicant-induced disruption. In this study the acute effects of cocaine on play behaviour in male and female Sprague-Dawley rats was assessed. Same-sex dyads of rats (postnatal day 35-36) were separated 24 h prior to testing. On the following day, one or both rats of the dyad were injected with the same dose of cocaine (0, 2.5, 5.0 or 20.00 mg/kg). Thirty minutes later the rats were placed together and, after 5 min of habituation, the frequency of pins and crawl-overs were measured for each subject. In dyads in which both rats were treated, crawl-overs and pinning behaviour were decreased by 20 mg/kg cocaine. In dyads in which only one rat was treated, there was marginal effect of cocaine treatment on pinning frequency, while crawl-overs were unaffected. Pinning frequency was not sexually dimorphic in either type of dyad; however, crawl-overs were more frequently exhibited by females in dyads in which only one rat was treated. Thus, pinning behaviour in juvenile rats appears somewhat more sensitive to cocaine-induced disruption than crawl-over behaviours. Additionally, the presence of an untreated rat appears to attenuate the play-disrupting effects of cocaine on pinning frequency.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0955-8810
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
175-9
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pubmed:dateRevised |
2009-7-7
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pubmed:meshHeading |
pubmed-meshheading:10877123-Animals,
pubmed-meshheading:10877123-Behavior, Animal,
pubmed-meshheading:10877123-Cocaine,
pubmed-meshheading:10877123-Dopamine Uptake Inhibitors,
pubmed-meshheading:10877123-Dose-Response Relationship, Drug,
pubmed-meshheading:10877123-Female,
pubmed-meshheading:10877123-Male,
pubmed-meshheading:10877123-Play and Playthings,
pubmed-meshheading:10877123-Rats,
pubmed-meshheading:10877123-Rats, Sprague-Dawley,
pubmed-meshheading:10877123-Sex Characteristics,
pubmed-meshheading:10877123-Social Behavior
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pubmed:year |
2000
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pubmed:articleTitle |
Acute effects of cocaine on play behaviour of rats.
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pubmed:affiliation |
Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, Arkansas 72079, USA. SFerguson@nctr.fda.gov
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pubmed:publicationType |
Journal Article
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