| pubmed-article:10876313 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10876313 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:10876313 | lifeskim:mentions | umls-concept:C0007097 | lld:lifeskim |
| pubmed-article:10876313 | lifeskim:mentions | umls-concept:C0677886 | lld:lifeskim |
| pubmed-article:10876313 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:10876313 | lifeskim:mentions | umls-concept:C0796357 | lld:lifeskim |
| pubmed-article:10876313 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:10876313 | pubmed:dateCreated | 2000-9-19 | lld:pubmed |
| pubmed-article:10876313 | pubmed:abstractText | beta-catenin is a continuously expressed cytoplasmic protein that has an important role is both E-cadherin-mediated cell-cell adhesion and in activation of Wnt/Wingless transcriptional pathway. The accumulation of stabilized beta-catenin caused by the mutation of the exon 3 of beta-catenin gene can stimulate the T-cell factor/Lymphoid enhancing factor-mediated transcriptional activation. The activation of transcriptional pathway may through oncogenes is an important step of the oncogenesis in solid tumors. In this study we analyzed mutations in exon 3 of the beta-catenin gene in 18 sporadic epithelial ovarian tumors. Three mutations were found from these 18 ovarian tumor samples which contained 8 serous, 3 mucinous, 5 endometrioid, one malignant Brenner-type tumor and one transitional cell carcinoma. Two mutations occurred in endometrioid-type (in 47 and 55 codons) and one in serous-type (in 47 codon) ovarian carcinomas, and both mutations were missense and somatic. The patients with mutated beta-catenin gene appeared from the younger patients under the age of 50. Our results suggest that the stabilization of beta-catenin protein by the mutation of CTNNB1 gene can contribute to the multistep process of the oncogenesis of epithelial ovarian tumors. Furthermore these mutations mostly occurs in the endometrioid-type of EOT, but can appear in other types such as serous-type ovarian tumor. | lld:pubmed |
| pubmed-article:10876313 | pubmed:language | hun | lld:pubmed |
| pubmed-article:10876313 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10876313 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10876313 | pubmed:month | May | lld:pubmed |
| pubmed-article:10876313 | pubmed:issn | 0030-6002 | lld:pubmed |
| pubmed-article:10876313 | pubmed:author | pubmed-author:NagyBB | lld:pubmed |
| pubmed-article:10876313 | pubmed:author | pubmed-author:PappZZ | lld:pubmed |
| pubmed-article:10876313 | pubmed:author | pubmed-author:TanyiJJ | lld:pubmed |
| pubmed-article:10876313 | pubmed:author | pubmed-author:RigóJJ | lld:pubmed |
| pubmed-article:10876313 | pubmed:author | pubmed-author:PáyAA | lld:pubmed |
| pubmed-article:10876313 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10876313 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:10876313 | pubmed:volume | 141 | lld:pubmed |
| pubmed-article:10876313 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10876313 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10876313 | pubmed:pagination | 1115-9 | lld:pubmed |
| pubmed-article:10876313 | pubmed:dateRevised | 2009-10-21 | lld:pubmed |
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| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
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| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:meshHeading | pubmed-meshheading:10876313... | lld:pubmed |
| pubmed-article:10876313 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10876313 | pubmed:articleTitle | [Mutation analysis of the beta-catenin gene in epithelial carcinomas of the ovaries]. | lld:pubmed |
| pubmed-article:10876313 | pubmed:affiliation | Altalános Orvostudományi Kar, Semmelweis Egyetem, Budapest. | lld:pubmed |
| pubmed-article:10876313 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10876313 | pubmed:publicationType | English Abstract | lld:pubmed |
