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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
21
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pubmed:dateCreated |
2000-9-19
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pubmed:abstractText |
beta-catenin is a continuously expressed cytoplasmic protein that has an important role is both E-cadherin-mediated cell-cell adhesion and in activation of Wnt/Wingless transcriptional pathway. The accumulation of stabilized beta-catenin caused by the mutation of the exon 3 of beta-catenin gene can stimulate the T-cell factor/Lymphoid enhancing factor-mediated transcriptional activation. The activation of transcriptional pathway may through oncogenes is an important step of the oncogenesis in solid tumors. In this study we analyzed mutations in exon 3 of the beta-catenin gene in 18 sporadic epithelial ovarian tumors. Three mutations were found from these 18 ovarian tumor samples which contained 8 serous, 3 mucinous, 5 endometrioid, one malignant Brenner-type tumor and one transitional cell carcinoma. Two mutations occurred in endometrioid-type (in 47 and 55 codons) and one in serous-type (in 47 codon) ovarian carcinomas, and both mutations were missense and somatic. The patients with mutated beta-catenin gene appeared from the younger patients under the age of 50. Our results suggest that the stabilization of beta-catenin protein by the mutation of CTNNB1 gene can contribute to the multistep process of the oncogenesis of epithelial ovarian tumors. Furthermore these mutations mostly occurs in the endometrioid-type of EOT, but can appear in other types such as serous-type ovarian tumor.
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pubmed:language |
hun
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CTNNB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Cadherins,
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/Glutamine,
http://linkedlifedata.com/resource/pubmed/chemical/Isoleucine,
http://linkedlifedata.com/resource/pubmed/chemical/Lysine,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0030-6002
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
21
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pubmed:volume |
141
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1115-9
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pubmed:dateRevised |
2009-10-21
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pubmed:meshHeading |
pubmed-meshheading:10876313-Adult,
pubmed-meshheading:10876313-Age Factors,
pubmed-meshheading:10876313-Aged,
pubmed-meshheading:10876313-Cadherins,
pubmed-meshheading:10876313-Carcinoma,
pubmed-meshheading:10876313-Cytoskeletal Proteins,
pubmed-meshheading:10876313-DNA, Neoplasm,
pubmed-meshheading:10876313-Female,
pubmed-meshheading:10876313-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:10876313-Glutamine,
pubmed-meshheading:10876313-Humans,
pubmed-meshheading:10876313-Isoleucine,
pubmed-meshheading:10876313-Lysine,
pubmed-meshheading:10876313-Middle Aged,
pubmed-meshheading:10876313-Mutation,
pubmed-meshheading:10876313-Neoplasm Staging,
pubmed-meshheading:10876313-Ovarian Neoplasms,
pubmed-meshheading:10876313-Polymerase Chain Reaction,
pubmed-meshheading:10876313-Serine,
pubmed-meshheading:10876313-Trans-Activators,
pubmed-meshheading:10876313-beta Catenin
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pubmed:year |
2000
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pubmed:articleTitle |
[Mutation analysis of the beta-catenin gene in epithelial carcinomas of the ovaries].
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pubmed:affiliation |
Altalános Orvostudományi Kar, Semmelweis Egyetem, Budapest.
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pubmed:publicationType |
Journal Article,
English Abstract
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