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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5475
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pubmed:dateCreated |
2000-7-24
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pubmed:abstractText |
Efferent feedback onto sensory organs provides a means to modulate input to the central nervous system. In the developing mammalian cochlea, inner hair cells are transiently innervated by efferent fibers, even before sensory function begins. Here, we show that neonatal inner hair cells are inhibited by cholinergic synaptic input before the onset of hearing. The synaptic currents, as well as the inner hair cell's response to acetylcholine, are mediated by a nicotinic (alpha9-containing) receptor and result in the activation of small-conductance calcium-dependent potassium channels.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2366-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:10875922-Acetylcholine,
pubmed-meshheading:10875922-Action Potentials,
pubmed-meshheading:10875922-Animals,
pubmed-meshheading:10875922-Animals, Newborn,
pubmed-meshheading:10875922-Apamin,
pubmed-meshheading:10875922-Bungarotoxins,
pubmed-meshheading:10875922-Calcium,
pubmed-meshheading:10875922-Cholinergic Antagonists,
pubmed-meshheading:10875922-Electric Conductivity,
pubmed-meshheading:10875922-Hair Cells, Auditory, Inner,
pubmed-meshheading:10875922-Neural Inhibition,
pubmed-meshheading:10875922-Neurons, Efferent,
pubmed-meshheading:10875922-Patch-Clamp Techniques,
pubmed-meshheading:10875922-Potassium,
pubmed-meshheading:10875922-Potassium Channels,
pubmed-meshheading:10875922-Rats,
pubmed-meshheading:10875922-Rats, Sprague-Dawley,
pubmed-meshheading:10875922-Receptors, Nicotinic,
pubmed-meshheading:10875922-Strychnine,
pubmed-meshheading:10875922-Synapses,
pubmed-meshheading:10875922-Synaptic Transmission
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pubmed:year |
2000
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pubmed:articleTitle |
Cholinergic synaptic inhibition of inner hair cells in the neonatal mammalian cochlea.
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pubmed:affiliation |
The Center for Hearing Sciences, Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. eglowatz@bme.jhu.edu
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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