Linked Life Data

1086875

Source:http://linkedlifedata.com/resource/pubmed/id/1086875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1977-1-25
pubmed:abstractText
The immunologic responses of 100 children hospitalized with meningitis due to Haemophilus influenzae type b were measured by the bactericidal antibody assay (BAA) and radioimmunoassay (RIA) for detection of antibody. Short-term (14-17 days after onset of illness) responses were detected by RIA alone in 20 children, by BAA alone in six, and by both tests in 23. The more sensitive RIA detected 20 children who would have been labeled "immunologically unresponsive" had only BAA been used. The magnitude of the antibody response was clearly related to age. Of 26 children with no immediate antibody response, 11 still had no rise in titer of antibody when restudied two to 20 months later; the remaining 15 had subsequent increases in titer. Nine of 10 children who showed an immediate antibody response remained positive when additional blood smaples were taken two to 18 months later. Over half of the children initially unresponsive to H. influenzae type b meningitis subsequently developed specific antibodies. The remainder, who failed to acquire detectable antibodies at either the acute stage of illness or late in convalescence, deserve further investigation as to the nature of their immunologic hyporesponsiveness to H. influenzae type b meningitis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-1899
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
495-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1976
pubmed:articleTitle
Serologic responses of children with meningitis due to Haemophilus influenzae type b.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.