Source:http://linkedlifedata.com/resource/pubmed/id/10861441
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
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pubmed:dateCreated |
2000-9-11
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pubmed:abstractText |
Compelling evidence indicates that paclitaxel kills cancer cells through the induction of apoptosis. Paclitaxel binds microtubules and causes kinetic suppression (stabilization) of microtubule dynamics. The consequent arrest of the cell cycle at mitotic phase has been considered to be the cause of paclitaxel-induced cytotoxicity. However, the biochemical events, downstream from paclitaxel's binding to microtubules, that lead to apoptosis are not well understood.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0008-543X
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2000 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2619-28
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10861441-Animals,
pubmed-meshheading:10861441-Antineoplastic Agents, Phytogenic,
pubmed-meshheading:10861441-Apoptosis,
pubmed-meshheading:10861441-Cell Cycle,
pubmed-meshheading:10861441-Cell Death,
pubmed-meshheading:10861441-Gene Expression,
pubmed-meshheading:10861441-Humans,
pubmed-meshheading:10861441-Microtubules,
pubmed-meshheading:10861441-Paclitaxel
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pubmed:year |
2000
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pubmed:articleTitle |
Paclitaxel-induced cell death: where the cell cycle and apoptosis come together.
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pubmed:affiliation |
Department of Obstetrics and Gynecology, Chang-Gung Memorial Hospital, Lin-Kou Medical Center, Tao-Yuan, Taiwan.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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