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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5472
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pubmed:dateCreated |
2000-6-29
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pubmed:abstractText |
HIV-1 sequences were analyzed to estimate the timing of the ancestral sequence of the main group of HIV-1, the strains responsible for the AIDS pandemic. Using parallel supercomputers and assuming a constant rate of evolution, we applied maximum-likelihood phylogenetic methods to unprecedented amounts of data for this calculation. We validated our approach by correctly estimating the timing of two historically documented points. Using a comprehensive full-length envelope sequence alignment, we estimated the date of the last common ancestor of the main group of HIV-1 to be 1931 (1915-41). Analysis of a gag gene alignment, subregions of envelope including additional sequences, and a method that relaxed the assumption of a strict molecular clock also supported these results.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
288
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1789-96
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:10846155-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10846155-Africa,
pubmed-meshheading:10846155-Animals,
pubmed-meshheading:10846155-Confidence Intervals,
pubmed-meshheading:10846155-Consensus Sequence,
pubmed-meshheading:10846155-Disease Outbreaks,
pubmed-meshheading:10846155-Europe,
pubmed-meshheading:10846155-Evolution, Molecular,
pubmed-meshheading:10846155-Genes, env,
pubmed-meshheading:10846155-HIV Envelope Protein gp160,
pubmed-meshheading:10846155-HIV-1,
pubmed-meshheading:10846155-Haiti,
pubmed-meshheading:10846155-Humans,
pubmed-meshheading:10846155-Likelihood Functions,
pubmed-meshheading:10846155-Pan troglodytes,
pubmed-meshheading:10846155-Phylogeny,
pubmed-meshheading:10846155-Simian Acquired Immunodeficiency Syndrome,
pubmed-meshheading:10846155-Simian immunodeficiency virus,
pubmed-meshheading:10846155-Time Factors,
pubmed-meshheading:10846155-United States,
pubmed-meshheading:10846155-Zoonoses
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pubmed:year |
2000
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pubmed:articleTitle |
Timing the ancestor of the HIV-1 pandemic strains.
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pubmed:affiliation |
Los Alamos National Laboratory, Los Alamos, NM 87545, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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