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rdf:type |
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lifeskim:mentions |
umls-concept:C0012727,
umls-concept:C0026809,
umls-concept:C0039194,
umls-concept:C0079411,
umls-concept:C0085358,
umls-concept:C0205094,
umls-concept:C0220905,
umls-concept:C0332285,
umls-concept:C0439662,
umls-concept:C1332717,
umls-concept:C1413244,
umls-concept:C1533691,
umls-concept:C1706438,
umls-concept:C2348205,
umls-concept:C2698600
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pubmed:issue |
7
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pubmed:dateCreated |
2000-6-14
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pubmed:abstractText |
When injected intravenously into naive mice, peritoneal exudate cells (PECs) incubated with ovalbumin (OVA) in the presence of transforming growth factor (TGF)-beta2 induce immune deviation similar to that evoked by injection of OVA into the anterior chamber of the eye. Intraocular antigen injection elicits two distinct populations of regulatory T cells that impair delayed hypersensitivity (DH) by two different mechanisms: a CD4+ T cell that suppresses the induction of DH (afferent) and a CD8+ T cell that inhibits DH expression. In an effort to understand the origin and mechanism of action of these regulatory cells, CD8+ T cells from OVA-specific T cell receptor (Tcr) transgenic mice (OT-1) were used.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1803-11
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10845601-Adoptive Transfer,
pubmed-meshheading:10845601-Animals,
pubmed-meshheading:10845601-Anterior Chamber,
pubmed-meshheading:10845601-Antigen-Presenting Cells,
pubmed-meshheading:10845601-CD8-Positive T-Lymphocytes,
pubmed-meshheading:10845601-Female,
pubmed-meshheading:10845601-Hypersensitivity, Delayed,
pubmed-meshheading:10845601-Interferon-gamma,
pubmed-meshheading:10845601-Interleukin-2,
pubmed-meshheading:10845601-Lymphocyte Activation,
pubmed-meshheading:10845601-Mice,
pubmed-meshheading:10845601-Mice, Inbred C57BL,
pubmed-meshheading:10845601-Mice, Transgenic,
pubmed-meshheading:10845601-Ovalbumin,
pubmed-meshheading:10845601-Peritoneal Cavity,
pubmed-meshheading:10845601-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:10845601-Transforming Growth Factor beta,
pubmed-meshheading:10845601-Tumor Necrosis Factor-alpha
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pubmed:year |
2000
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pubmed:articleTitle |
In vitro generation of regulatory CD8+ T cells similar to those found in mice with anterior chamber-associated immune deviation.
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pubmed:affiliation |
Schepens Eye Research Institute, Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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