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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1976-9-1
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pubmed:abstractText |
Lymphoid cells from twenty-four untreated Hodgkin's disease biopsies were examined for spontaneous sheep erythrocyte and sensitized ox erythrocyte rosette formation for the identification of T cell and cells with Fc and C3 receptors and surface immunoglobulin. Compared with normal tissues mean T-lymphocytes values were elevated in both involved lymph nodes and uninvolved spleens from Hodgkin's patients. Lymphocytes bearing C3 receptors were correspondingly reduced in these tissues. Involved spleen T-cell values fell within the normal range. In normal tissues the sum of lymphocytes with surface immunoglobulin and sheep erythrocyte receptors fell in the range 89-108%. In six biopsies of Hodgkin's tissue the sum was outside the normal range (121-142%). This observation is compatible with surface immunoglobulin-coated T cells. Surface marker characteristics and intracellular immunoglobulin studies of small lymphocytes, lymphoblasts and Hodgkin's cells suggested that the neoplastic cells were of B lymphocyte origin.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-13673565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-13928229,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-14011436,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-14378492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4101362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4110054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4114496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4118369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4118652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4124423,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4124458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4132252,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4132991,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4133226,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4135566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4136032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4138221,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4139576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4203007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4281669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4545783,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4549576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4576536,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4590767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4613371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4617644,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-46472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-4744582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1084241-5337005
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
280-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1084241-Adolescent,
pubmed-meshheading:1084241-Adult,
pubmed-meshheading:1084241-Aged,
pubmed-meshheading:1084241-B-Lymphocytes,
pubmed-meshheading:1084241-Biopsy,
pubmed-meshheading:1084241-Complement C3,
pubmed-meshheading:1084241-Female,
pubmed-meshheading:1084241-Histiocytes,
pubmed-meshheading:1084241-Hodgkin Disease,
pubmed-meshheading:1084241-Humans,
pubmed-meshheading:1084241-Immune Adherence Reaction,
pubmed-meshheading:1084241-Immunoglobulin Fc Fragments,
pubmed-meshheading:1084241-Immunoglobulin G,
pubmed-meshheading:1084241-Leukocyte Count,
pubmed-meshheading:1084241-Lymph Nodes,
pubmed-meshheading:1084241-Male,
pubmed-meshheading:1084241-Middle Aged,
pubmed-meshheading:1084241-Receptors, Antigen, B-Cell,
pubmed-meshheading:1084241-Spleen,
pubmed-meshheading:1084241-T-Lymphocytes
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pubmed:year |
1976
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pubmed:articleTitle |
T and B lymphocytes and Reed-Sternberg cells in Hodgkin's disease lymph nodes and spleens.
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pubmed:publicationType |
Journal Article
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