rdf:type |
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0021655,
umls-concept:C0028754,
umls-concept:C0030705,
umls-concept:C0299583,
umls-concept:C0332281,
umls-concept:C0332307,
umls-concept:C0441889,
umls-concept:C0681850,
umls-concept:C1363984,
umls-concept:C1453722,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1882417,
umls-concept:C2349001,
umls-concept:C2697811
|
pubmed:issue |
6
|
pubmed:dateCreated |
2000-9-18
|
pubmed:abstractText |
Mice lacking the tumor necrosis factor-alpha receptor 2 (TNFR2) gene fed a high-fat diet gain less weight and display reduced leptin and insulin levels. In humans, plasma levels of the soluble fraction of TNFR2 (sTNFR2) circulate in proportion to the degree of insulin resistance. The purpose of this study was to evaluate a polymorphism in the 3' untranslated region of the TNFR2 gene on chromosome 1 in relation to BMI, leptin levels, and insulin resistance.
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pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3' Untranslated Regions,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Leptin,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Tumor Necrosis Factor...,
http://linkedlifedata.com/resource/pubmed/chemical/leptin receptor, human,
http://linkedlifedata.com/resource/pubmed/chemical/leptin receptor, mouse
|
pubmed:status |
MEDLINE
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pubmed:month |
Jun
|
pubmed:issn |
0149-5992
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
23
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
831-7
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:10841005-3' Untranslated Regions,
pubmed-meshheading:10841005-Adipose Tissue,
pubmed-meshheading:10841005-Adult,
pubmed-meshheading:10841005-Alleles,
pubmed-meshheading:10841005-Animals,
pubmed-meshheading:10841005-Antigens, CD,
pubmed-meshheading:10841005-Diabetes Mellitus, Type 2,
pubmed-meshheading:10841005-Diabetic Diet,
pubmed-meshheading:10841005-Female,
pubmed-meshheading:10841005-Genetic Predisposition to Disease,
pubmed-meshheading:10841005-Genetic Variation,
pubmed-meshheading:10841005-Humans,
pubmed-meshheading:10841005-Insulin Resistance,
pubmed-meshheading:10841005-Leptin,
pubmed-meshheading:10841005-Male,
pubmed-meshheading:10841005-Mice,
pubmed-meshheading:10841005-Mice, Knockout,
pubmed-meshheading:10841005-Middle Aged,
pubmed-meshheading:10841005-Obesity,
pubmed-meshheading:10841005-Polymorphism, Single-Stranded Conformational,
pubmed-meshheading:10841005-Receptors, Leptin,
pubmed-meshheading:10841005-Receptors, Tumor Necrosis Factor,
pubmed-meshheading:10841005-Receptors, Tumor Necrosis Factor, Type II,
pubmed-meshheading:10841005-Reference Values
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pubmed:year |
2000
|
pubmed:articleTitle |
Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients.
|
pubmed:affiliation |
Diabetes Unit, Endocrinology and Nutrition, University Hospital of Girona Dr. Josep Trueta, Barcelona, Spain. endocrino@htrueta.scs.es
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|