Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2000-9-18
pubmed:abstractText
Mice lacking the tumor necrosis factor-alpha receptor 2 (TNFR2) gene fed a high-fat diet gain less weight and display reduced leptin and insulin levels. In humans, plasma levels of the soluble fraction of TNFR2 (sTNFR2) circulate in proportion to the degree of insulin resistance. The purpose of this study was to evaluate a polymorphism in the 3' untranslated region of the TNFR2 gene on chromosome 1 in relation to BMI, leptin levels, and insulin resistance.
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0149-5992
pubmed:author
pubmed:issnType
Print
pubmed:volume
23
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
831-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:10841005-3' Untranslated Regions, pubmed-meshheading:10841005-Adipose Tissue, pubmed-meshheading:10841005-Adult, pubmed-meshheading:10841005-Alleles, pubmed-meshheading:10841005-Animals, pubmed-meshheading:10841005-Antigens, CD, pubmed-meshheading:10841005-Diabetes Mellitus, Type 2, pubmed-meshheading:10841005-Diabetic Diet, pubmed-meshheading:10841005-Female, pubmed-meshheading:10841005-Genetic Predisposition to Disease, pubmed-meshheading:10841005-Genetic Variation, pubmed-meshheading:10841005-Humans, pubmed-meshheading:10841005-Insulin Resistance, pubmed-meshheading:10841005-Leptin, pubmed-meshheading:10841005-Male, pubmed-meshheading:10841005-Mice, pubmed-meshheading:10841005-Mice, Knockout, pubmed-meshheading:10841005-Middle Aged, pubmed-meshheading:10841005-Obesity, pubmed-meshheading:10841005-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:10841005-Receptors, Leptin, pubmed-meshheading:10841005-Receptors, Tumor Necrosis Factor, pubmed-meshheading:10841005-Receptors, Tumor Necrosis Factor, Type II, pubmed-meshheading:10841005-Reference Values
pubmed:year
2000
pubmed:articleTitle
Polymorphism of the tumor necrosis factor-alpha receptor 2 gene is associated with obesity, leptin levels, and insulin resistance in young subjects and diet-treated type 2 diabetic patients.
pubmed:affiliation
Diabetes Unit, Endocrinology and Nutrition, University Hospital of Girona Dr. Josep Trueta, Barcelona, Spain. endocrino@htrueta.scs.es
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't