Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2000-7-7
pubmed:abstractText
Hepatocyte nuclear factor 6 (HNF-6) is the prototype of a new class of cut homeodomain transcription factors. During mouse development, HNF-6 is expressed in the epithelial cells that are precursors of the exocrine and endocrine pancreatic cells. We have investigated the role of HNF-6 in pancreas differentiation by inactivating its gene in the mouse. In hnf6(-/-) embryos, the exocrine pancreas appeared to be normal but endocrine cell differentiation was impaired. The expression of neurogenin 3 (Ngn-3), a transcription factor that is essential for determination of endocrine cell precursors, was almost abolished. Consistent with this, we demonstrated that HNF-6 binds to and stimulates the ngn3 gene promoter. At birth, only a few endocrine cells were found and the islets of Langerhans were missing. Later, the number of endocrine cells increased and islets appeared. However, the architecture of the islets was perturbed, and their beta cells were deficient in glucose transporter 2 expression. Adult hnf6(-/-) mice were diabetic. Taken together, our data demonstrate that HNF-6 controls pancreatic endocrine differentiation at the precursor stage and identify HNF-6 as the first positive regulator of the proendocrine gene ngn3 in the pancreas. They also suggest that HNF-6 is a candidate gene for diabetes mellitus in humans.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10471501, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10471502, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10476967, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10567564, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10615124, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10640277, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10677506, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-10868931, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-7600975, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-7935793, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-7937805, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-8243817, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-8602241, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-8631275, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-8702531, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-8790352, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9000074, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9108377, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9121556, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9163426, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9224716, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9308961, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9315659, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9354799, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9441664, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9441665, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9584121, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9593691, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9603781, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9836511, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9851981, http://linkedlifedata.com/resource/pubmed/commentcorrection/10825208-9915796
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0270-7306
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4445-54
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3.
pubmed:affiliation
Hormone and Metabolic Research Unit, Université catholique de Louvain and Christian de Duve Institute of Cellular Pathology, 1200 Brussels, Belgium.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't