Source:http://linkedlifedata.com/resource/pubmed/id/10823701
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
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pubmed:dateCreated |
2000-9-20
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pubmed:abstractText |
The methanolic extract and ethyl acetate-soluble portion from the flowers of Chrysanthemum indicum L., Chrysanthemi Indici Flos, were found to show inhibitory activity against nitric oxide (NO) production in lipopolysaccharide-activated macrophages. Five new germacrane-type sesquiterpenes, kikkanols D, D monoacetate, E, F, and F monoacetate, were isolated from the ethyl acetate-soluble portion. Their absolute stereostructures were elucidated on the basis of chemical and physicochemical evidence, which included application of the modified Mosher's method. The effects of fifteen principal components from the ethyl acetate-soluble portion of this medicinal flower against NO production were examined and, among them, acetylenic compounds and flavonoids were found to show potent inhibitory activity.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-2363
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
651-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10823701-Animals,
pubmed-meshheading:10823701-Chrysanthemum cinerariifolium,
pubmed-meshheading:10823701-Enzyme Inhibitors,
pubmed-meshheading:10823701-Macrophages, Peritoneal,
pubmed-meshheading:10823701-Magnetic Resonance Spectroscopy,
pubmed-meshheading:10823701-Male,
pubmed-meshheading:10823701-Mice,
pubmed-meshheading:10823701-Molecular Conformation,
pubmed-meshheading:10823701-Nitric Oxide Synthase,
pubmed-meshheading:10823701-Plants, Medicinal,
pubmed-meshheading:10823701-Sesquiterpenes,
pubmed-meshheading:10823701-Spectrophotometry, Infrared
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pubmed:year |
2000
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pubmed:articleTitle |
Medicinal flowers. II. Inhibitors of nitric oxide production and absolute stereostructures of five new germacrane-type sesquiterpenes, kikkanols D, D monoacetate, E, F, and F monoacetate from the flowers of Chrysanthemum indicum L.
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pubmed:affiliation |
Kyoto Pharmaceutical University, Japan. shoyaku@mb.kyoto-phu.ac.jp
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pubmed:publicationType |
Journal Article,
In Vitro
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