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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1976-3-30
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pubmed:abstractText |
Lymphoid cells from spleen and lymph nodes of BALB/c mice were sensitized in vitro by cocultivation with cells from syngeneic methylcholanthrene-induced sarcomas. The donor mice were either immunized in vivo by tumor transplantation followed by excision ("tumor-excised mice") or were carrying a progressively growing tumor ("tumor-bearing mice"). The cell-mediated immune response of the sensitized cells was compared by a 36-hr microcytotoxicity assay. Lymphoid cells from tumor-excised mice were cytotoxic when tested after 3 days and also after 6 days of sensitization in vitro. Lymphoid cells from tumor-bearing mice were cytotoxic to cells of the tumor borne when tested after 3 days in culture. However, the cytotoxic effect was lost after 6 days of contact with the sensitizing tumor in vitro. Preliminary data suggest that the cultured lymphoid cells of tumor-bearing mice which have lost cytotoxicity, can suppress the reactivity of in vitro sensitized lymphoid cells from tumor-excised mice.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-1112984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-123545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-165006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-185057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-236258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4131386,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4133584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4151912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4194429,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4417443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4541509,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4570016,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4699052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-4947774,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1082135-51523
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5086-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1082135-Animals,
pubmed-meshheading:1082135-Antigens, Neoplasm,
pubmed-meshheading:1082135-B-Lymphocytes,
pubmed-meshheading:1082135-Cell Line,
pubmed-meshheading:1082135-Immunization,
pubmed-meshheading:1082135-Mice,
pubmed-meshheading:1082135-Mice, Inbred BALB C,
pubmed-meshheading:1082135-Sarcoma, Experimental,
pubmed-meshheading:1082135-T-Lymphocytes
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pubmed:year |
1975
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pubmed:articleTitle |
Different responses of lymphoid cells from tumor-bearing as compared to tumor-immunized mice when sensitized to tumor specific antigens in vitro.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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