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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2000-6-5
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pubmed:abstractText |
We investigated the molecular mechanism by which Sph-1-P affects the FN-dependent haptotactic motility of serum-starved mouse melanoma B16/F10 cells. We found that EDG-5-induced Rho activation followed by enhanced tyrosine phosphorylation of FAK and paxillin, and beta 1-integrin activation leading to overexpression of focal adhesion sites, as well as increment of stress fiber formation, must be the molecular basis of inhibition of haptotactic cell motility by Sph-1-P.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytoskeletal Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Kinase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Focal Adhesion Protein-Tyrosine...,
http://linkedlifedata.com/resource/pubmed/chemical/GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Lysophospholipids,
http://linkedlifedata.com/resource/pubmed/chemical/Paxillin,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Ptk2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Pxn protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Lysophospholipid,
http://linkedlifedata.com/resource/pubmed/chemical/Sphingosine,
http://linkedlifedata.com/resource/pubmed/chemical/sphingosine 1-phosphate
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0077-8923
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
905
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
301-7
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:10818470-3T3 Cells,
pubmed-meshheading:10818470-Animals,
pubmed-meshheading:10818470-Base Sequence,
pubmed-meshheading:10818470-Cytoskeletal Proteins,
pubmed-meshheading:10818470-DNA Primers,
pubmed-meshheading:10818470-Focal Adhesion Kinase 1,
pubmed-meshheading:10818470-Focal Adhesion Protein-Tyrosine Kinases,
pubmed-meshheading:10818470-GTP-Binding Proteins,
pubmed-meshheading:10818470-Lysophospholipids,
pubmed-meshheading:10818470-Melanoma, Experimental,
pubmed-meshheading:10818470-Mice,
pubmed-meshheading:10818470-Paxillin,
pubmed-meshheading:10818470-Phosphoproteins,
pubmed-meshheading:10818470-Phosphorylation,
pubmed-meshheading:10818470-Protein-Tyrosine Kinases,
pubmed-meshheading:10818470-RNA, Messenger,
pubmed-meshheading:10818470-Receptors, Cell Surface,
pubmed-meshheading:10818470-Receptors, G-Protein-Coupled,
pubmed-meshheading:10818470-Receptors, Lysophospholipid,
pubmed-meshheading:10818470-Sphingosine,
pubmed-meshheading:10818470-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Sphingosine-1-phosphate inhibits haptotactic motility by overproduction of focal adhesion sites in B16 melanoma cells through EDG-induced activation of Rho.
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pubmed:affiliation |
Department of Pathobiology, University of Washington, Seattle, USA.
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pubmed:publicationType |
Journal Article
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