Source:http://linkedlifedata.com/resource/pubmed/id/10801962
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5S Suppl
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pubmed:dateCreated |
2000-6-8
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pubmed:abstractText |
Zinc is essential to the structure and function of myriad proteins, including regulatory, structural and enzymatic. It is estimated that up to 1% of the human genome codes for zinc finger proteins. In the central nervous system, zinc has an additional role as a neurosecretory product or cofactor. In this role, zinc is highly concentrated in the synaptic vesicles of a specific contingent of neurons, called "zinc-containing" neurons. Zinc-containing neurons are a subset of glutamatergic neurons. The zinc in the vesicles probably exceeds 1 mmol/L in concentration and is only weakly coordinated with any endogenous ligand. Zinc-containing neurons are found almost exclusively in the forebrain, where in mammals they have evolved into a complex and elaborate associational network that interconnects most of the cerebral cortices and limbic structures. Indeed, one of the intriguing aspects of these neurons is that they compose somewhat of a chemospecific "private line" of the mammalian cerebral cortex. The present review outlines (1) the methods used to discover, define and describe zinc-containing neurons; (2) the neuroarchitecture and synaptology of zinc-containing neural circuits; (3) the physiology of regulated vesicular zinc release; (4) the "life cycle" and molecular biology of vesicular zinc; (5) the importance of synaptically released zinc in the normal and pathological processes of the cerebral cortex; and (6) the role of specific and nonspecific stressors in the release of zinc.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cation Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SLC30A3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Zinc
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-3166
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1471S-83S
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pubmed:dateRevised |
2005-11-16
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pubmed:meshHeading |
pubmed-meshheading:10801962-Alzheimer Disease,
pubmed-meshheading:10801962-Animals,
pubmed-meshheading:10801962-Brain,
pubmed-meshheading:10801962-Carrier Proteins,
pubmed-meshheading:10801962-Cation Transport Proteins,
pubmed-meshheading:10801962-Central Nervous System,
pubmed-meshheading:10801962-Humans,
pubmed-meshheading:10801962-Membrane Proteins,
pubmed-meshheading:10801962-Molecular Biology,
pubmed-meshheading:10801962-Neurons,
pubmed-meshheading:10801962-Synaptic Vesicles,
pubmed-meshheading:10801962-Zinc
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pubmed:year |
2000
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pubmed:articleTitle |
Importance of zinc in the central nervous system: the zinc-containing neuron.
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pubmed:affiliation |
NeuroBio Tex, Inc., Galveston, TX 77550, USA.
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pubmed:publicationType |
Journal Article,
Review
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