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rdf:type |
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lifeskim:mentions |
umls-concept:C0007600,
umls-concept:C0010592,
umls-concept:C0014406,
umls-concept:C0017262,
umls-concept:C0021107,
umls-concept:C0021670,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0205369,
umls-concept:C1280500,
umls-concept:C1515655,
umls-concept:C1522326
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pubmed:issue |
7
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pubmed:dateCreated |
2000-5-25
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pubmed:abstractText |
Transplantation of engineered beta cell-derived lines is a promising modality for cell-based therapy of diabetes mellitus. The in vivo environment and antirejection and other medications may have significant effects on the differentiation and proliferation of the transplanted beta cells, thus affecting their function. The effect of the in vivo environment on expression of genes encoding proteins involved in insulin production, secretion, and glucose sensing were analyzed in the RIN 104638 cell line.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Actins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporine,
http://linkedlifedata.com/resource/pubmed/chemical/Glucokinase,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose Transporter Type 2,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Monosaccharide Transport Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators,
http://linkedlifedata.com/resource/pubmed/chemical/pancreatic and duodenal homeobox 1...
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0041-1337
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
69
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1464-70
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:10798772-Actins,
pubmed-meshheading:10798772-Animals,
pubmed-meshheading:10798772-B-Lymphocytes,
pubmed-meshheading:10798772-Cyclosporine,
pubmed-meshheading:10798772-Gene Expression,
pubmed-meshheading:10798772-Glucokinase,
pubmed-meshheading:10798772-Glucose Transporter Type 2,
pubmed-meshheading:10798772-Homeodomain Proteins,
pubmed-meshheading:10798772-Insulin,
pubmed-meshheading:10798772-Insulinoma,
pubmed-meshheading:10798772-Male,
pubmed-meshheading:10798772-Monosaccharide Transport Proteins,
pubmed-meshheading:10798772-Neoplasm Transplantation,
pubmed-meshheading:10798772-Pancreatic Neoplasms,
pubmed-meshheading:10798772-RNA, Messenger,
pubmed-meshheading:10798772-Rats,
pubmed-meshheading:10798772-Trans-Activators,
pubmed-meshheading:10798772-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Implantation of rat insulinoma cell line into cyclosporine treated rats. Effect of the in vivo environment on beta-cell specific gene expression.
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pubmed:affiliation |
Institute of Endocrinology, Chaim Sheba Medical Center, Tel Hashomer, Israel.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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