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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2000-7-13
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pubmed:abstractText |
Glutathione S-transferase (GST) plays a major role in the detoxification of the potent hepatocarcinogen aflatoxin B(1) (AFB(1)). This study evaluated the effects of intermittent exposures to AFB(1) on hepatic and testicular GST in rats. Male Fischer 344 rats were fed diets containing AFB(1) (0, 0.01, 0.04, 0.4 and 1.6 ppm) intermittently at 4-week intervals up to 20 weeks. The control animals were fed an AFB(1)-free NIH-31 diet. Rats consuming diets with 0.01 ppm AFB(1) did not show the induction of hepatic or testicular GST activity. Intermittent exposures to AFB(1) at concentrations of 0.04-1.6 ppm significantly increased the GST activities. The increase of the enzyme activity was proportional to the dose and length of AFB(1) exposure.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0260-437X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2000 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
20
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-9
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:10797475-Aflatoxin B1,
pubmed-meshheading:10797475-Animals,
pubmed-meshheading:10797475-Body Weight,
pubmed-meshheading:10797475-Carcinogens,
pubmed-meshheading:10797475-DNA Adducts,
pubmed-meshheading:10797475-Diet,
pubmed-meshheading:10797475-Glutathione Transferase,
pubmed-meshheading:10797475-Liver,
pubmed-meshheading:10797475-Male,
pubmed-meshheading:10797475-Metabolic Detoxication, Drug,
pubmed-meshheading:10797475-Organ Size,
pubmed-meshheading:10797475-Rats,
pubmed-meshheading:10797475-Rats, Inbred F344,
pubmed-meshheading:10797475-Testis
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pubmed:articleTitle |
Effects of intermittent exposures of aflatoxin B(1) on hepatic and testicular glutathione S-transferase in rats.
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pubmed:affiliation |
Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, MD 20708, USA.
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pubmed:publicationType |
Journal Article
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