Linked Life Data

1079468

Source:http://linkedlifedata.com/resource/pubmed/id/1079468

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1975-9-9
pubmed:abstractText
Prostaglandin E1 (PGE1) has been tested by microiontophoresis on interneurons and motoneurons in the isolated spinal cord of the frog. PGE1 action was almost exclusively excitatory, regardless of the cell type and the test condition used. In general, the excitatory response had rapid onset and termination, and was susceptible to tachyphylaxis. Responsive interneurons were scattered throughout the tissue, and the incidence of responses showed no obvious relation to the mono- vs. polysynaptic connection of cells to primary afferents and descending fibers of the lateral funiculus. PGE1-sensitive interneurons were encountered more often in preparations from summer than from winter animals. These findings, coupled with the demonstration of prostaglandin biosynthesis and catabolism in the tissue, suggest that PGE1 plays a role in the normal function of spinal neurons. The intimate mechanism of PGE1 action remains to be elucidated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0008-4212
pubmed:author
pubmed:issnType
Print
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
273-84
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Responses of spinal neurons to iontophoretically applied prostaglandin E1 in the frog.
pubmed:publicationType
Journal Article, In Vitro