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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1395
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pubmed:dateCreated |
2000-6-28
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pubmed:abstractText |
To understand how memory CD4 T cells are generated we have re-examined the requirements for continuing antigen stimulation in the generation and persistence of this population. We find that specific antigen is only required for a short period during the activation of naive CD4 T cells and is not required for memory generation from activated CD4 T cells or for persistence of resting memory cells generated by transfer of activated CD4 to adoptive hosts. Moreover, transfer of activated CD4 T cells to class-II-deficient hosts, indicates that TcR-class II major histocompatibility interaction is also unnecessary for either the transition from activated CD4 T cell to resting memory cells or for persistence over an eight-week period. Thus the signals regulating generation and maintenance of memory are fundamentally different from those which regulate the expansion of effector CD4 T-cell populations which include antigen itself and the CD4 T-cell autocrine cytokines induced by antigen.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-1944559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-2571940,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-7541426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-7600283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-7650478,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-8782706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-8920876,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-9151709,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-9197272,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-9252125,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-9501216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-9651253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/10794062-9780149
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0962-8436
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
355
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
407-11
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
2000
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pubmed:articleTitle |
CD4 T-cell memory can persist in the absence of class II.
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pubmed:affiliation |
Trudeau Institute, Saranac Lake, NY 12983, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Review,
Research Support, Non-U.S. Gov't
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