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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2000-6-26
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pubmed:abstractText |
Multidrug resistance (MDR) to cancer chemotherapy is frequently associated with decreased drug accumulation in cancer cells due to drug expulsion by multidrug transporters such as P-glycoprotein (Pgp) and multidrug resistance protein (MRP). The novel resistance modifying agents PSC 833, 280-446, and LY 335979 are primarily targeted at inhibition of Pgp, and their MRP inhibitory potential is largely unknown.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibiotics, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Antineoplastic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclosporins,
http://linkedlifedata.com/resource/pubmed/chemical/Daunorubicin,
http://linkedlifedata.com/resource/pubmed/chemical/Dibenzocycloheptenes,
http://linkedlifedata.com/resource/pubmed/chemical/P-Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolines,
http://linkedlifedata.com/resource/pubmed/chemical/SDZ 280 446,
http://linkedlifedata.com/resource/pubmed/chemical/valspodar,
http://linkedlifedata.com/resource/pubmed/chemical/zosuquidar trihydrochloride
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0946-1965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
187-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:10783828-Antibiotics, Antineoplastic,
pubmed-meshheading:10783828-Antineoplastic Agents,
pubmed-meshheading:10783828-Cyclosporins,
pubmed-meshheading:10783828-Daunorubicin,
pubmed-meshheading:10783828-Dibenzocycloheptenes,
pubmed-meshheading:10783828-Drug Resistance, Multiple,
pubmed-meshheading:10783828-Drug Resistance, Neoplasm,
pubmed-meshheading:10783828-Flow Cytometry,
pubmed-meshheading:10783828-Fluorescence,
pubmed-meshheading:10783828-Humans,
pubmed-meshheading:10783828-Leukemia, Myeloid,
pubmed-meshheading:10783828-P-Glycoproteins,
pubmed-meshheading:10783828-Peptides, Cyclic,
pubmed-meshheading:10783828-Quinolines,
pubmed-meshheading:10783828-Tumor Cells, Cultured
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pubmed:year |
2000
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pubmed:articleTitle |
Diverse effects of P-glycoprotein inhibitory agents on human leukemia cells expressing the multidrug resistance protein (MRP).
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pubmed:affiliation |
Department of Clinical Pharmacology, Institute for Surgical Reseach, The National Hospital, Rikshospitalet, University of Oslo, Norway.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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