| pubmed-article:10779751 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C0039401 | lld:lifeskim |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C0014406 | lld:lifeskim |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C0439677 | lld:lifeskim |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C0302828 | lld:lifeskim |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:10779751 | lifeskim:mentions | umls-concept:C1516240 | lld:lifeskim |
| pubmed-article:10779751 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:10779751 | pubmed:dateCreated | 2000-5-22 | lld:pubmed |
| pubmed-article:10779751 | pubmed:abstractText | Dendritic cells (DC) are key initiators of primary immune responses. Myeloid DC can secrete IL-12, a potent Th1-driving factor, and are often viewed as Th1-promoting APC. Here we show that neither a Th1- nor a Th2-inducing function is an intrinsic attribute of human myeloid DC, but both depend on environmental instruction. Uncommitted immature DC require exposure to IFN-gamma, at the moment of induction of their maturation or shortly thereafter, to develop the capacity to produce high levels of IL-12p70 upon subsequent contact with naive Th cells. This effect is specific for IFN-gamma and is not shared by other IL-12-inducing factors. Type 1-polarized effector DC, matured in the presence of IFN-gamma, induce Th1 responses, in contrast to type 2-polarized DC matured in the presence of PGE2 that induce Th2 responses. Type 1-polarized effector DC are resistant to further modulation, which may facilitate their potential use in immunotherapy. | lld:pubmed |
| pubmed-article:10779751 | pubmed:language | eng | lld:pubmed |
| pubmed-article:10779751 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10779751 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:10779751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10779751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10779751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:10779751 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:10779751 | pubmed:month | May | lld:pubmed |
| pubmed-article:10779751 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:10779751 | pubmed:author | pubmed-author:KapsenbergM... | lld:pubmed |
| pubmed-article:10779751 | pubmed:author | pubmed-author:WierengaE AEA | lld:pubmed |
| pubmed-article:10779751 | pubmed:author | pubmed-author:Kali?skiPP | lld:pubmed |
| pubmed-article:10779751 | pubmed:author | pubmed-author:de JongE CEC | lld:pubmed |
| pubmed-article:10779751 | pubmed:author | pubmed-author:VieiraP LPL | lld:pubmed |
| pubmed-article:10779751 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:10779751 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:10779751 | pubmed:volume | 164 | lld:pubmed |
| pubmed-article:10779751 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:10779751 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:10779751 | pubmed:pagination | 4507-12 | lld:pubmed |
| pubmed-article:10779751 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:meshHeading | pubmed-meshheading:10779751... | lld:pubmed |
| pubmed-article:10779751 | pubmed:year | 2000 | lld:pubmed |
| pubmed-article:10779751 | pubmed:articleTitle | Development of Th1-inducing capacity in myeloid dendritic cells requires environmental instruction. | lld:pubmed |
| pubmed-article:10779751 | pubmed:affiliation | Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands. | lld:pubmed |
| pubmed-article:10779751 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:10779751 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:10779751 | lld:pubmed |
