rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3-4
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pubmed:dateCreated |
2000-7-27
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pubmed:abstractText |
It has been shown that macrophage migration inhibitory factor (MIF) modulates not only macrophage functions, but also T cell functions. However, detailed analysis of the MIF function on responses of various T cell subpopulations remained to be elucidated. In this report, using a neutralizing anti-MIF monoclonal antibody (mAb) we examined MIF functions on various T cell lineages. It was shown that anti-MIF mAb inhibited antigen-specific responses of both IFN-gamma producing and IL-4 producing T cells. The inhibition appeared to be related to blockade of the signal pathway via T cell receptor (TCR) but not that via IL-2 receptor (IL-2R). However, the anti-MIF mAb showed no inhibitory effect on NK-T cell responses stimulated through TCR. These results suggest that MIF is involved in the signal pathway via TCR in mainstream T cells but not in NK-T cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/KLRB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/Macrophage Migration-Inhibitory...,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interleukin-2
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0171-2985
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
356-67
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:10776792-Amino Acid Sequence,
pubmed-meshheading:10776792-Animals,
pubmed-meshheading:10776792-Antibodies, Monoclonal,
pubmed-meshheading:10776792-Antibody Specificity,
pubmed-meshheading:10776792-Antigens,
pubmed-meshheading:10776792-Antigens, Surface,
pubmed-meshheading:10776792-Cell Division,
pubmed-meshheading:10776792-Cell Line,
pubmed-meshheading:10776792-Humans,
pubmed-meshheading:10776792-Killer Cells, Natural,
pubmed-meshheading:10776792-Lectins, C-Type,
pubmed-meshheading:10776792-Lymphocyte Activation,
pubmed-meshheading:10776792-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:10776792-Mice,
pubmed-meshheading:10776792-Mice, Inbred BALB C,
pubmed-meshheading:10776792-Mice, Inbred C57BL,
pubmed-meshheading:10776792-Molecular Sequence Data,
pubmed-meshheading:10776792-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:10776792-Proteins,
pubmed-meshheading:10776792-Receptors, Antigen, T-Cell,
pubmed-meshheading:10776792-Receptors, Interleukin-2,
pubmed-meshheading:10776792-Signal Transduction,
pubmed-meshheading:10776792-T-Lymphocyte Subsets
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pubmed:year |
2000
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pubmed:articleTitle |
Different influence of macrophage migration inhibitory factor (MIF) in signal transduction pathway of various T cell subsets.
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pubmed:affiliation |
Institute of Immunological Science Hokkaido University, Department of Ophthalmology, Sapporo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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