|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2000-6-26
|
|
pubmed:abstractText |
Dynamic chromatin remodeling during B cell differentiation was identified in the vicinity of J chain gene. In pre-B cells, the enhancer-containing DNase I hypersensitive sites (HSSs) 3-4 were open. However, these HSSs 3-4 turned out to be unassociated with J chain gene expression, as the J chain promoter-containing HSS1 remained in a closed state. The open enhancer HSSs 3-4 in the pre-B cells might be related to the expression of a pre-B cell-specific gene upstream of the HSSs 3-4, which was identified in our Northern blot analyses. The HSSs 3-4 are then closed in the next immature and mature B cell stages until the IL-2 opens the HSSs 3-4 again as well as HSS1 to express J chain gene in the primary immune responses. The dynamic regulation of chromatin structure during B cell differentiation for the expression of two stage-specific genes will provide a good model system for the study of B cell differentiation and gene expression.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1016-8478
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
29
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
32-7
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:10774744-Animals,
pubmed-meshheading:10774744-B-Lymphocytes,
pubmed-meshheading:10774744-Base Sequence,
pubmed-meshheading:10774744-Binding Sites,
pubmed-meshheading:10774744-Cell Differentiation,
pubmed-meshheading:10774744-Cell Line,
pubmed-meshheading:10774744-Chromatin,
pubmed-meshheading:10774744-DNA,
pubmed-meshheading:10774744-DNA Footprinting,
pubmed-meshheading:10774744-Deoxyribonuclease I,
pubmed-meshheading:10774744-Enhancer Elements, Genetic,
pubmed-meshheading:10774744-Gene Expression Regulation,
pubmed-meshheading:10774744-Genes, Immunoglobulin,
pubmed-meshheading:10774744-Hematopoietic Stem Cells,
pubmed-meshheading:10774744-Immunoglobulin J-Chains,
pubmed-meshheading:10774744-Molecular Sequence Data,
pubmed-meshheading:10774744-Plasma Cells,
pubmed-meshheading:10774744-Promoter Regions, Genetic,
pubmed-meshheading:10774744-Sulfuric Acid Esters,
pubmed-meshheading:10774744-Tumor Cells, Cultured
|
|
pubmed:year |
2000
|
|
pubmed:articleTitle |
Dynamic chromatin remodeling in the vicinity of J chain gene for the regulation of two stage-specific genes during B cell differentiation.
|
|
pubmed:affiliation |
Sensory Research Group, Creative Research Initiatives, College of Pharmacy, Seoul National University, Korea. chjkang@plaza1.snu.ac.kr
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
