Linked Life Data

10772709

Source:http://linkedlifedata.com/resource/pubmed/id/10772709

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2000-7-31
pubmed:abstractText
Liquid chromatography was used to follow the degradation of hexopyranosylated cytosine nucleosides in buffers of acid, neutral and alkaline pH and of constant ionic strength. The compounds were found to degrade by hydrolysis to cytosine and/or by deamination to the corresponding uracil nucleosides. Degradation in acid is influenced by the number of sugar hydroxyl groups, presence of sugar double bonds and the type of anomer. Stability of some of the compounds was compared with that of related thymine nucleosides. Temperature studies support a unimolecular mechanism of hydrolysis at pH 1.22.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1525-7770
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
189-203
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:articleTitle
Investigation of the kinetics of degradation of hexopyranosylated cytosine nucleosides using liquid chromatography.
pubmed:affiliation
Katholieke Universiteit Leuven, Laboratorium voor Farmaceutische Chemie en Analyse, Faculteit Farmaceutische Wetenschappen, Belgium.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't